Influence of retinoids on skin fibroblasts metabolism in vitro

The most dangerous environmental factor for our skin condition is ultraviolet light radiation. Chronic exposition to ultraviolet light can induce epidermal atrophy, keratosis, depigmentation and dysplasia. In the dermis, UV light causes dramatic up-regulation of extracellular matrix-degrading enzyme...

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Bibliographic Details
Published in:Acta Poloniae pharmaceutica Vol. 65; no. 1; p. 85
Main Authors: Jurzak, Magdalena, Latocha, Małgorzata, Gojniczek, Katarzyna, Kapral, Małgorzata, Garncarczyk, Agnieszka, Pierzchała, Ewa
Format: Journal Article
Language:English
Published: Poland 01.01.2008
Subjects:
Cell Proliferation - drug effects
Cell Survival - drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Fibroblasts - drug effects
Fibroblasts - metabolism
Gene Expression Regulation - drug effects
Humans
In Vitro Techniques
Keratolytic Agents - administration & dosage
Keratolytic Agents - pharmacology
Matrix Metalloproteinases - drug effects
Matrix Metalloproteinases - metabolism
Skin - drug effects
Skin - metabolism
Tretinoin - administration & dosage
Tretinoin - pharmacology
ISSN:0001-6837
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Summary:The most dangerous environmental factor for our skin condition is ultraviolet light radiation. Chronic exposition to ultraviolet light can induce epidermal atrophy, keratosis, depigmentation and dysplasia. In the dermis, UV light causes dramatic up-regulation of extracellular matrix-degrading enzymes. Matrix metalloproteinases (MMPs) are engaged in collagen, elastin and other extracellular matrix components degradation. In addition, to increase level of destructive enzymes, UV light has been shown to decrease collagen production. As a consequence of UV impact on skin, it shows signs of aging including loss of tone and elasticity, increased skin fragility, blood vessels weakness and wrinkles. The most dangerous effect of UV on skin is an increased risk of melanoma and other skin cancers. Retinoids are well known antiaging agents. For many years this vitamin has been used for the prevention and treatment of photoaging. Retinoids abolish cellular atypia, increase compacting of the stratum corneum and reduce skin hyperpigmentation caused by sun light. Recent evidence suggests that retinoids also play a role in the prevention of aging, because of its inhibitory effects on metalloproteinases expression. The aim of this study was to examine if all-trans-retinoic acid (ATRA) effects MMP-1, MMP-2, MMP-3 and MMP-14 gene expression in fibroblasts cultured in vitro.
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ISSN:0001-6837