Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model

The murine Leishmania major model has proven fertile ground for the elucidation of CD4+ T cell effector subset differentiation in vivo. The availability of a highly susceptible inbred strain, BALB/c, that develops progressive disease due to the aberrant differentiation of Th2, as opposed to protecti...

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Vydáno v:European cytokine network (Montrouge) Ročník 9; číslo 3 Suppl; s. 102
Hlavní autoři: Fowell, D J, Bix, M, Shinkai, K, Lacy, D, Locksley, R M
Médium: Journal Article
Jazyk:angličtina
Vydáno: France 01.09.1998
Témata:
Animals
Cytokines - biosynthesis
Disease Models, Animal
Disease Susceptibility - immunology
Leishmania major - immunology
Leishmaniasis, Cutaneous - genetics
Leishmaniasis, Cutaneous - immunology
Mice
Mice, Inbred BALB C
ISSN:1148-5493
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Shrnutí:The murine Leishmania major model has proven fertile ground for the elucidation of CD4+ T cell effector subset differentiation in vivo. The availability of a highly susceptible inbred strain, BALB/c, that develops progressive disease due to the aberrant differentiation of Th2, as opposed to protective Th1, responses, has allowed the identification of both T cell intrinsic as well as T cell extrinsic properties that combine to mediate disease outcome. The intrinsic T cell phenotype relates to the capacity of BALB/c-derived CD4+ T cells to acquire the potential to secrete IL-4 more readily than cells from other strains of mice. The extrinsic T cell phenotype relates to the creation of a T cell repertoire capable of recognizing the immunodominant parasite antigen. Together, the two traits confer the aberrant response seen in susceptible mice challenged with L. major.
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ISSN:1148-5493