Disease susceptibility and development of the cytokine repertoire in the murine Leishmania major model

The murine Leishmania major model has proven fertile ground for the elucidation of CD4+ T cell effector subset differentiation in vivo. The availability of a highly susceptible inbred strain, BALB/c, that develops progressive disease due to the aberrant differentiation of Th2, as opposed to protecti...

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Bibliographic Details
Published in:	European cytokine network (Montrouge) Vol. 9; no. 3 Suppl; p. 102
Main Authors:	Fowell, D J, Bix, M, Shinkai, K, Lacy, D, Locksley, R M
Format:	Journal Article
Language:	English
Published:	France 01.09.1998
Subjects:	Animals Cytokines - biosynthesis Disease Models, Animal Disease Susceptibility - immunology Leishmania major - immunology Leishmaniasis, Cutaneous - genetics Leishmaniasis, Cutaneous - immunology Mice Mice, Inbred BALB C
ISSN:	1148-5493
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Summary:	The murine Leishmania major model has proven fertile ground for the elucidation of CD4+ T cell effector subset differentiation in vivo. The availability of a highly susceptible inbred strain, BALB/c, that develops progressive disease due to the aberrant differentiation of Th2, as opposed to protective Th1, responses, has allowed the identification of both T cell intrinsic as well as T cell extrinsic properties that combine to mediate disease outcome. The intrinsic T cell phenotype relates to the capacity of BALB/c-derived CD4+ T cells to acquire the potential to secrete IL-4 more readily than cells from other strains of mice. The extrinsic T cell phenotype relates to the creation of a T cell repertoire capable of recognizing the immunodominant parasite antigen. Together, the two traits confer the aberrant response seen in susceptible mice challenged with L. major.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1148-5493