Actinobacillus actinomycetemcomitans and Bacteroides gingivalis activate human peripheral monocytes to produce interleukin-1 and tumor necrosis factor

The effects of gram-negative bacteria clearly associated with juvenile and adult periodontitis on monokine production were assessed using standard in vitro assay techniques. Actinobacillus actinomycetemcomitans and Bacteroides gingivalis were able to activate human peripheral blood monocytes to prod...

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Bibliographic Details
Published in:Journal of periodontology (1970) Vol. 59; no. 11; p. 728
Main Authors: Lindemann, R A, Economou, J S
Format: Journal Article
Language:English
Published: United States 01.11.1988
Subjects:
Actinobacillus - physiology
Bacteroides - physiology
Bone Resorption - etiology
Interleukin-1 - biosynthesis
Monocytes - metabolism
Periodontitis - microbiology
Tumor Necrosis Factor-alpha - biosynthesis
ISSN:0022-3492
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Summary:The effects of gram-negative bacteria clearly associated with juvenile and adult periodontitis on monokine production were assessed using standard in vitro assay techniques. Actinobacillus actinomycetemcomitans and Bacteroides gingivalis were able to activate human peripheral blood monocytes to produce significant amounts of interleukin-1 (IL-1) and tumor necrosis factor (TNF). These monokines are known to induce osteoclastic bone resorption. An oral gram-positive organism, Staphylococcus epidermidis, was able to induce only modest amounts of IL-1 and TNF, slightly above unstimulated monocyte levels.
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ISSN:0022-3492
DOI:10.1902/jop.1988.59.11.728