Glycosphingolipids of porcine blood: human blood group A and H antigens with type 1 chain in erythrocytes and plasma

Glycosphingolipids were purified from porcine erythrocytes and plasma. Two minor glycolipids with human blood group A and H antigenicities were found in both sources as components. The two antigenic glycolipids were identified as a hexaglycosylceramide (IV3 alpha GalNAc,IV2 alpha Fuc-Lc4Cer) for the...

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Vydané v:Indian journal of biochemistry & biophysics Ročník 27; číslo 6; s. 402
Hlavní autori: Makita, A, Gasa, S, Sako, F, Hanagata, G
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: India 01.12.1990
Predmet:
Animals
Blood Group Antigens - immunology
Carbohydrate Sequence
Ceramides - blood
Ceramides - classification
Erythrocytes - immunology
Gangliosides - blood
Gangliosides - classification
Gas Chromatography-Mass Spectrometry
Glycosphingolipids - blood
Glycosphingolipids - classification
Glycosphingolipids - isolation & purification
Humans
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Plasma - immunology
Sulfoglycosphingolipids - blood
Sulfoglycosphingolipids - classification
Swine - blood
ISSN:0301-1208
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Shrnutí:Glycosphingolipids were purified from porcine erythrocytes and plasma. Two minor glycolipids with human blood group A and H antigenicities were found in both sources as components. The two antigenic glycolipids were identified as a hexaglycosylceramide (IV3 alpha GalNAc,IV2 alpha Fuc-Lc4Cer) for the A antigen and pentaglycosylceramide (IV2 alpha Fuc-Lc4Cer) for the H antigen and belonged to lactoseries (type 1 sugar chain) in contrast to those with neolacto core (type 2 sugar chain) in human erythrocytes, thereby endorsing biochemically the previous serological observations that the A antigen on porcine erythrocytes is uptake from plasma, probably the H antigen being the case. In addition to major glycolipids of globoseries in red cells and plasma, a variety of acidic glycolipids including two classes of sulphatides (sulphated galactosylceramide and sulphated lactosylceramide) and five classes of gangliosides (GM3, GD3, GM1, fucosyl GM1 and GD1a) containing N-acetylneuraminic acid and N-glycolylneuraminic acid were obtained from plasma.
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ISSN:0301-1208