Clustering WHO-ART terms using semantic distance and machine learning algorithms
WHO-ART was developed by the WHO collaborating centre for international drug monitoring in order to code adverse drug reactions. We assume that computation of semantic distance between WHO-ART terms may be an efficient way to group related medical conditions in the WHO database in order to improve s...
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| Vydáno v: | AMIA ... Annual Symposium proceedings s. 369 |
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| Jazyk: | angličtina |
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United States
2006
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| ISSN: | 1942-597X, 1559-4076 |
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| Abstract | WHO-ART was developed by the WHO collaborating centre for international drug monitoring in order to code adverse drug reactions. We assume that computation of semantic distance between WHO-ART terms may be an efficient way to group related medical conditions in the WHO database in order to improve signal detection. Our objective was to develop a method for clustering WHO-ART terms according to some proximity of their meanings. Our material comprises 758 WHO-ART terms. A formal definition was acquired for each term as a list of elementary concepts belonging to SNOMED international axes and characterized by modifier terms in some cases. Clustering was implemented as a terminology service on a J2EE server. Two different unsupervised machine learning algorithms (KMeans, Pvclust) clustered WHO-ART terms according to a semantic distance operator previously described. Pvclust grouped 51% of WHO-ART terms. K-Means grouped 100% of WHO-ART terms but 25% clusters were heterogeneous with k = 180 clusters and 6% clusters were heterogeneous with k = 32 clusters. Clustering algorithms associated to semantic distance could suggest potential groupings of WHO-ART terms that need validation according to the user's requirements. |
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| AbstractList | WHO-ART was developed by the WHO collaborating centre for international drug monitoring in order to code adverse drug reactions. We assume that computation of semantic distance between WHO-ART terms may be an efficient way to group related medical conditions in the WHO database in order to improve signal detection. Our objective was to develop a method for clustering WHO-ART terms according to some proximity of their meanings. Our material comprises 758 WHO-ART terms. A formal definition was acquired for each term as a list of elementary concepts belonging to SNOMED international axes and characterized by modifier terms in some cases. Clustering was implemented as a terminology service on a J2EE server. Two different unsupervised machine learning algorithms (KMeans, Pvclust) clustered WHO-ART terms according to a semantic distance operator previously described. Pvclust grouped 51% of WHO-ART terms. K-Means grouped 100% of WHO-ART terms but 25% clusters were heterogeneous with k = 180 clusters and 6% clusters were heterogeneous with k = 32 clusters. Clustering algorithms associated to semantic distance could suggest potential groupings of WHO-ART terms that need validation according to the user's requirements.WHO-ART was developed by the WHO collaborating centre for international drug monitoring in order to code adverse drug reactions. We assume that computation of semantic distance between WHO-ART terms may be an efficient way to group related medical conditions in the WHO database in order to improve signal detection. Our objective was to develop a method for clustering WHO-ART terms according to some proximity of their meanings. Our material comprises 758 WHO-ART terms. A formal definition was acquired for each term as a list of elementary concepts belonging to SNOMED international axes and characterized by modifier terms in some cases. Clustering was implemented as a terminology service on a J2EE server. Two different unsupervised machine learning algorithms (KMeans, Pvclust) clustered WHO-ART terms according to a semantic distance operator previously described. Pvclust grouped 51% of WHO-ART terms. K-Means grouped 100% of WHO-ART terms but 25% clusters were heterogeneous with k = 180 clusters and 6% clusters were heterogeneous with k = 32 clusters. Clustering algorithms associated to semantic distance could suggest potential groupings of WHO-ART terms that need validation according to the user's requirements. WHO-ART was developed by the WHO collaborating centre for international drug monitoring in order to code adverse drug reactions. We assume that computation of semantic distance between WHO-ART terms may be an efficient way to group related medical conditions in the WHO database in order to improve signal detection. Our objective was to develop a method for clustering WHO-ART terms according to some proximity of their meanings. Our material comprises 758 WHO-ART terms. A formal definition was acquired for each term as a list of elementary concepts belonging to SNOMED international axes and characterized by modifier terms in some cases. Clustering was implemented as a terminology service on a J2EE server. Two different unsupervised machine learning algorithms (KMeans, Pvclust) clustered WHO-ART terms according to a semantic distance operator previously described. Pvclust grouped 51% of WHO-ART terms. K-Means grouped 100% of WHO-ART terms but 25% clusters were heterogeneous with k = 180 clusters and 6% clusters were heterogeneous with k = 32 clusters. Clustering algorithms associated to semantic distance could suggest potential groupings of WHO-ART terms that need validation according to the user's requirements. |
| Author | Jaulent, Marie-Christine Iavindrasana, Jimison Degoulet, Patrice Bousquet, Cedric |
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| References | 11079852 - Proc AMIA Symp. 2000;:96-100 9865050 - Methods Inf Med. 1998 Nov;37(4-5):518-26 11144660 - Drug Saf. 2000 Dec;23(6):533-42 17108617 - Stud Health Technol Inform. 2006;124:839-44 9656658 - Methods Inf Med. 1998 Jun;37(2):161-4 9696956 - Eur J Clin Pharmacol. 1998 Jun;54(4):315-21 |
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| SubjectTerms | Adverse Drug Reaction Reporting Systems Algorithms Artificial Intelligence Humans Semantics Subject Headings Systematized Nomenclature of Medicine Unified Medical Language System Vocabulary, Controlled World Health Organization |
| Title | Clustering WHO-ART terms using semantic distance and machine learning algorithms |
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