Increased levels of the oxidative stress biomarker 8-iso-prostaglandin F 2α in wastewater associated with tobacco use

Wastewater analysis has been demonstrated to be a complementary approach for assessing the overall patterns of drug use by a population while the full potential of wastewater-based epidemiology has yet to be explored. F -isoprostanes are a prototype wastewater biomarker to study the cumulative oxida...

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Veröffentlicht in:Scientific reports Jg. 6; S. 39055
Hauptverfasser: Ryu, Yeonsuk, Gracia-Lor, Emma, Bade, Richard, Baz-Lomba, J A, Bramness, Jørgen G, Castiglioni, Sara, Castrignanò, Erika, Causanilles, Ana, Covaci, Adrian, de Voogt, Pim, Hernandez, Felix, Kasprzyk-Hordern, Barbara, Kinyua, Juliet, McCall, Ann-Kathrin, Ort, Christoph, Plósz, Benedek G, Ramin, Pedram, Rousis, Nikolaos I, Reid, Malcolm J, Thomas, Kevin V
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 15.12.2016
Schlagworte:
Biomarkers - analysis
Cities
Cotinine - analogs & derivatives
Cotinine - analysis
Dinoprost - analogs & derivatives
Dinoprost - analysis
Europe
Humans
Norway
Oxidative Stress
Regression Analysis
Sulfuric Acid Esters - analysis
Tobacco Use - epidemiology
Urbanization
Waste Water - analysis
ISSN:2045-2322
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Zusammenfassung:Wastewater analysis has been demonstrated to be a complementary approach for assessing the overall patterns of drug use by a population while the full potential of wastewater-based epidemiology has yet to be explored. F -isoprostanes are a prototype wastewater biomarker to study the cumulative oxidative stress at a community level. In this work, 8-iso-prostaglandin F (8-iso-PGF ) was analysed in raw 24 h-composite wastewater samples collected from 4 Norwegian and 7 other European cities in 2014 and 2015. Using the same samples, biomarkers of alcohol (ethyl sulfate) and tobacco (trans-3'-hydroxycotinine) use were also analysed to investigate any possible correlation between 8-iso-PGF and the consumption of the two drugs. The estimated per capita daily loads of 8-iso-PGF in the 11 cities ranged between 2.5 and 9.9 mg/day/1000 inhabitants with a population-weighted mean of 4.8 mg/day/1000 inhabitants. There were no temporal trends observed in the levels of 8-iso-PGF , however, spatial differences were found at the inter-city level correlating to the degree of urbanisation. The 8-iso-PGF mass load was found to be strongly associated with that of trans-3'-hydroxycotinine while it showed no correlation with ethyl sulfate. The present study shows the potential for 8-iso-PGF as a wastewater biomarker for the assessment of community public health.
ISSN:2045-2322
DOI:10.1038/srep39055