NAT10 and N4-acetylcytidine restrain R-loop levels and related inflammatory responses

N4-acetylcytidine (ac4C) is deposited on diverse RNAs by N-acetyltransferase 10 (NAT10), a protein with high biological relevance for aging and cancer. We performed a comprehensive survey of ac4C using metabolic labeling, sodium cyanoborohydride chemical treatment coupled to next-generation sequenci...

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Bibliographic Details

Published in:	Science advances Vol. 11; no. 13; p. eads6144
Main Authors:	Debnath, Turja K, Abell, Nathan S, Li, Yi-Ru, Devanathan, Sravan K, Navedo, Enrique, Xhemalçe, Blerta
Format:	Journal Article
Language:	English
Published:	American Association for the Advancement of Science 26.03.2025
Subjects:	Biomedicine and Life Sciences Cell Biology Molecular Biology SciAdv r-articles
ISSN:	2375-2548, 2375-2548
Online Access:	Get full text
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