Control of Leishmania major by a monoclonal alpha beta T cell repertoire

Little is known regarding the diversity of the host T cell response that is required to maintain immunologic control of microbial pathogens. Leishmania major persist as obligate intracellular parasites within macrophages of the mammalian host. Immunity is dependent upon activation of MHC class II-re...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 160; no. 2; p. 884
Main Authors:	Reiner, S L, Fowell, D J, Moskowitz, N H, Swier, K, Brown, D R, Brown, C R, Turck, C W, Scott, P A, Killeen, N, Locksley, R M
Format:	Journal Article
Language:	English
Published:	United States 15.01.1998
Subjects:	Amino Acid Sequence Animals Antigens, Protozoan - biosynthesis Antigens, Protozoan - genetics Antigens, Protozoan - immunology Clone Cells Leishmania major - genetics Leishmania major - immunology Leishmaniasis, Cutaneous - genetics Leishmaniasis, Cutaneous - prevention & control Lymphocyte Activation - drug effects Lymphocyte Activation - genetics Macrophages - immunology Macrophages - parasitology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Mice, Transgenic Molecular Sequence Data Protozoan Proteins - biosynthesis Protozoan Proteins - genetics Protozoan Proteins - pharmacology Receptors, Antigen, T-Cell, alpha-beta - genetics Recombinant Proteins - pharmacology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - parasitology
ISSN:	0022-1767
Online Access:	Get more information
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