scPER: A Rigorous Computational Approach to Determine Cellular Subtypes in Tumors Aligned With Cancer Phenotypes From Total RNA Sequencing

Single-cell RNA sequencing (scRNA-seq) is a powerful technique for understanding cellular diversity, but processing large patient cohorts to identify phenotype-associated cell populations remains challenging. Here, scPER (Estimating cell Proportions using single-cell RNA-seq Reference), a rigorous a...

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Bibliographic Details
Published in:Advanced science p. e14502
Main Authors: Li, Bingrui, Zhou, Xiaobo, Kalluri, Raghu
Format: Journal Article
Language:English
Published: Germany 27.11.2025
Subjects:
deconvolution
cancer biology
tumor microenvironment
machine learning
ISSN:2198-3844, 2198-3844
Online Access:Get full text
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