Vulvar intraepithelial neoplasia

The authors reviewed the records of 50 patients with carcinoma in situ of the vulva seen at the State University of New York at Buffalo affiliated hospitals. Five patients (10%) were found to be immunosuppressed and 12 (24%) had other preinvasive and invasive genital or extragenital neoplasia. Of 43...

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Vydáno v:Obstetrics and gynecology (New York. 1953) Ročník 60; číslo 3; s. 346
Hlavní autoři: Caglar, H, Tamer, S, Hreshchyshyn, M M
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.09.1982
Témata:
Adolescent
Adult
Aged
Carcinoma in Situ - complications
Carcinoma in Situ - diagnosis
Carcinoma in Situ - therapy
Female
Fluorouracil - therapeutic use
Humans
Immunosuppression
Laser Therapy
Middle Aged
Neoplasms, Multiple Primary - diagnosis
Pruritus Vulvae - diagnosis
Vulvar Neoplasms - complications
Vulvar Neoplasms - diagnosis
Vulvar Neoplasms - therapy
ISSN:0029-7844
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Shrnutí:The authors reviewed the records of 50 patients with carcinoma in situ of the vulva seen at the State University of New York at Buffalo affiliated hospitals. Five patients (10%) were found to be immunosuppressed and 12 (24%) had other preinvasive and invasive genital or extragenital neoplasia. Of 43 patients whose symptomatology was available, almost half (46.5%) were asymptomatic. The most common symptom was vulvar itching in 18 (42%), and 32 (65%) patients had white vulvar lesions. Thirteen patients underwent vulvectomy, 23 underwent wide local excision, 8 underwent skinning and skin graft, 3 underwent topical 5-fluorouracil treatment, and 2 underwent CO2 laser treatment. On follow-up there were 6 patients with recurrent and/or persistent disease. Two recurrences followed wide local excision. Topical 5-fluorouracil failed in all 3 patients and CO2 laser failed in 1 of the 2 underwent laser treatment. There were 5 patients with invasive disease. In 3, diagnostic biopsy failed to reveal invasive neoplasia before surgical excision, and invasion was noted after 5-fluorouracil application in one and after CO2 laser treatment in another. All recurrences responded to therapy. In 41 patients followed up for 3 months to 11 years, there were no cancer-related deaths.
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ISSN:0029-7844