Crushed Prasugrel Tablets in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention: The CRUSH Study

Platelet inhibitory effects induced by oral P2Y12 receptor antagonists are delayed in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI), which may be attributed to impaired absorption affecting drug pharmacokinetics (PK) and...

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Bibliographic Details
Published in:	Journal of the American College of Cardiology Vol. 67; no. 17; p. 1994
Main Authors:	Rollini, Fabiana, Franchi, Francesco, Hu, Jenny, Kureti, Megha, Aggarwal, Niti, Durairaj, Ashwin, Park, Yongwhi, Seawell, Michael, Cox-Alomar, Pedro, Zenni, Martin M, Guzman, Luis A, Suryadevara, Siva, Antoun, Patrick, Bass, Theodore A, Angiolillo, Dominick J
Format:	Journal Article
Language:	English
Published:	United States 03.05.2016
Subjects:	Female Humans Male Middle Aged Percutaneous Coronary Intervention Platelet Aggregation Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - blood Platelet Aggregation Inhibitors - pharmacokinetics Prasugrel Hydrochloride - administration & dosage Prasugrel Hydrochloride - blood Prasugrel Hydrochloride - pharmacokinetics Prospective Studies Receptors, Purinergic P2Y12 - blood ST Elevation Myocardial Infarction - therapy Tablets crushed tablet pharmacodynamic pharmacokinetic platelets
ISSN:	1558-3597, 1558-3597
Online Access:	Get more information
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