Guinea pig auditory nerve response triggered by a high density electrode array

The electrically evoked potential in the auditory nerve is measured when the cochlear is stimulated with a high density electrode array whose microcontacts (20 x 160 microns) are placed close to the nerve cells. Threshold range from 8 to 35 microA with the stimulating electrodes near the spiral gang...

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Bibliographic Details
Published in:Medical progress through technology Vol. 21 Suppl; p. 13
Main Authors: Jolly, C N, Clopton, B M, Spelman, F A, Lineaweaver, S K
Format: Journal Article
Language:English
Published: United States 1997
Subjects:
Action Potentials - physiology
Animals
Auditory Threshold - physiology
Cochlear Implantation
Cochlear Implants
Cochlear Nerve - physiology
Cochlear Nucleus - physiology
Deafness - physiopathology
Dendrites - physiology
Dendrites - ultrastructure
Electric Stimulation
Evoked Potentials, Auditory - physiology
Guinea Pigs
Microelectrodes
Neurons - physiology
Neurons - ultrastructure
Prosthesis Design
Reaction Time
Spiral Ganglion - physiology
Spiral Ganglion - ultrastructure
Vestibulocochlear Nerve - physiology
ISSN:0047-6552
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Summary:The electrically evoked potential in the auditory nerve is measured when the cochlear is stimulated with a high density electrode array whose microcontacts (20 x 160 microns) are placed close to the nerve cells. Threshold range from 8 to 35 microA with the stimulating electrodes near the spiral ganglion cells. A multi-pole technique for restricting the spread of current with electrical stimulation of the cochlea is tested using neural recording in deafened guinea pigs. The ground based quadrupolar electrode driving configuration has thresholds for neural activation only slightly greater than monopolar stimulation when the electrode contacts are placed less than 50 microns from the neurons. During simultaneous stimulation the monopole and the ground based quadrupolar modes tend to generate similar growth functions (magnitude and latency). The electrode interactions are generally factorial, which means that the algebraic sum of the responses (magnitude growth functions) produced by 2 distinct electrodes is less than when the same 2 electrodes are stimulated simultaneously.
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ISSN:0047-6552