Δ(9)-Tetrahydrocannabinol acts as a partial agonist/antagonist in mice

Δ-Tetrahydrocannabinol (THC) has been characterized as a partial agonist at cannabinoid CB1 receptors in vitro; however, it often produces the same maximum effects in vivo as other cannabinoid agonists. This study was carried out to determine whether THC would antagonize the hypothermic effects of a...

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Vydáno v:	Behavioural pharmacology Ročník 23; číslo 8; s. 802
Hlavní autoři:	Paronis, Carol A, Nikas, Spyros P, Shukla, Vidyanand G, Makriyannis, Alexandros
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 01.12.2012
Témata:	Animals Benzopyrans - administration & dosage Benzopyrans - pharmacology Cannabinoid Receptor Agonists - administration & dosage Cannabinoid Receptor Agonists - pharmacology Dose-Response Relationship, Drug Dronabinol - administration & dosage Dronabinol - pharmacology Hypothermia - chemically induced Hypothermia - prevention & control Male Mice Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - antagonists & inhibitors Time Factors
ISSN:	1473-5849, 1473-5849
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