The baseline assessment of the German National Cohort (NAKO Gesundheitsstudie): participation in the examination modules, quality assurance, and the use of secondary data

The German National Cohort (NAKO) is an interdisciplinary health study aimed at elucidating causes for common chronic diseases and detecting their preclinical stages. This article provides an overview of design, methods, participation in the examinations, and their quality assurance based on the mid...

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Vydáno v:Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz Ročník 63; číslo 3; s. 254
Hlavní autoři: Schipf, Sabine, Schöne, Gina, Schmidt, Börge, Günther, Kathrin, Stübs, Gunthard, Greiser, Karin H, Bamberg, Fabian, Meinke-Franze, Claudia, Becher, Heiko, Berger, Klaus, Brenner, Hermann, Castell, Stefanie, Damms-Machado, Antje, Fischer, Beate, Franzke, Claus-Werner, Fricke, Julia, Gastell, Sylvia, Günther, Matthias, Hoffmann, Wolfgang, Holleczek, Bernd, Jaeschke, Lina, Jagodzinski, Annika, Jöckel, Karl-Heinz, Kaaks, Rudolf, Kauczor, Hans-Ulrich, Kemmling, Yvonne, Kluttig, Alexander, Krist, Lilian, Kurth, Bärbel, Kuß, Oliver, Legath, Nicole, Leitzmann, Michael, Lieb, Wolfgang, Linseisen, Jakob, Löffler, Markus, Michels, Karin B, Mikolajczyk, Rafael, Pigeot, Iris, Mueller, Ulrich, Peters, Annette, Rach, Stefan, Schikowski, Tamara, Schulze, Matthias B, Stallmann, Christoph, Stang, Andreas, Swart, Enno, Waniek, Sabine, Wirkner, Kerstin, Völzke, Henry, Pischon, Tobias, Ahrens, Wolfgang
Médium: Journal Article
Jazyk:němčina
Vydáno: Germany 01.03.2020
Témata:
Adult
Aged
Chronic Disease
Cohort Studies
Epidemiologic Studies
Female
Germany
Health Status
Humans
Male
Middle Aged
Registries
Surveys and Questionnaires
Young Adult
Germany
Quality assurance
Biosamples
MRI
Cohort study
Response proportion
ISSN:1437-1588, 1437-1588
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Abstract The German National Cohort (NAKO) is an interdisciplinary health study aimed at elucidating causes for common chronic diseases and detecting their preclinical stages. This article provides an overview of design, methods, participation in the examinations, and their quality assurance based on the midterm baseline dataset (MBD) of the recruitment. More than 200,000 women and men aged 20-69 years derived from random samples of the German general population were recruited in 18 study centers (2014-2019). The data collection comprised physical examinations, standardized interviews and questionnaires, and the collection of biomedical samples for all participants (level 1). At least 20% of all participants received additional in-depth examinations (level 2), and 30,000 received whole-body magnet resonance imaging (MRI). Additional information will be collected through secondary data sources such as medical registries, health insurances, and pension funds. This overview is based on the MBD, which included 101,839 participants, of whom 11,371 received an MRI. The mean response proportion was 18%. The participation in the examinations was high with most of the modules performed by over 95%. Among MRI participants, 96% completed all 12 MRI sequences. More than 90% of the participants agreed to the use of complementary secondary and registry data. Individuals selected for the NAKO were willing to participate in all examinations despite the time-consuming program. The NAKO provides a central resource for population-based epidemiologic research and will contribute to developing innovative strategies for prevention, screening and prediction of chronic diseases.
AbstractList The German National Cohort (NAKO) is an interdisciplinary health study aimed at elucidating causes for common chronic diseases and detecting their preclinical stages. This article provides an overview of design, methods, participation in the examinations, and their quality assurance based on the midterm baseline dataset (MBD) of the recruitment.BACKGROUNDThe German National Cohort (NAKO) is an interdisciplinary health study aimed at elucidating causes for common chronic diseases and detecting their preclinical stages. This article provides an overview of design, methods, participation in the examinations, and their quality assurance based on the midterm baseline dataset (MBD) of the recruitment.More than 200,000 women and men aged 20-69 years derived from random samples of the German general population were recruited in 18 study centers (2014-2019). The data collection comprised physical examinations, standardized interviews and questionnaires, and the collection of biomedical samples for all participants (level 1). At least 20% of all participants received additional in-depth examinations (level 2), and 30,000 received whole-body magnet resonance imaging (MRI). Additional information will be collected through secondary data sources such as medical registries, health insurances, and pension funds. This overview is based on the MBD, which included 101,839 participants, of whom 11,371 received an MRI.METHODSMore than 200,000 women and men aged 20-69 years derived from random samples of the German general population were recruited in 18 study centers (2014-2019). The data collection comprised physical examinations, standardized interviews and questionnaires, and the collection of biomedical samples for all participants (level 1). At least 20% of all participants received additional in-depth examinations (level 2), and 30,000 received whole-body magnet resonance imaging (MRI). Additional information will be collected through secondary data sources such as medical registries, health insurances, and pension funds. This overview is based on the MBD, which included 101,839 participants, of whom 11,371 received an MRI.The mean response proportion was 18%. The participation in the examinations was high with most of the modules performed by over 95%. Among MRI participants, 96% completed all 12 MRI sequences. More than 90% of the participants agreed to the use of complementary secondary and registry data.RESULTSThe mean response proportion was 18%. The participation in the examinations was high with most of the modules performed by over 95%. Among MRI participants, 96% completed all 12 MRI sequences. More than 90% of the participants agreed to the use of complementary secondary and registry data.Individuals selected for the NAKO were willing to participate in all examinations despite the time-consuming program. The NAKO provides a central resource for population-based epidemiologic research and will contribute to developing innovative strategies for prevention, screening and prediction of chronic diseases.DISCUSSIONIndividuals selected for the NAKO were willing to participate in all examinations despite the time-consuming program. The NAKO provides a central resource for population-based epidemiologic research and will contribute to developing innovative strategies for prevention, screening and prediction of chronic diseases.
The German National Cohort (NAKO) is an interdisciplinary health study aimed at elucidating causes for common chronic diseases and detecting their preclinical stages. This article provides an overview of design, methods, participation in the examinations, and their quality assurance based on the midterm baseline dataset (MBD) of the recruitment. More than 200,000 women and men aged 20-69 years derived from random samples of the German general population were recruited in 18 study centers (2014-2019). The data collection comprised physical examinations, standardized interviews and questionnaires, and the collection of biomedical samples for all participants (level 1). At least 20% of all participants received additional in-depth examinations (level 2), and 30,000 received whole-body magnet resonance imaging (MRI). Additional information will be collected through secondary data sources such as medical registries, health insurances, and pension funds. This overview is based on the MBD, which included 101,839 participants, of whom 11,371 received an MRI. The mean response proportion was 18%. The participation in the examinations was high with most of the modules performed by over 95%. Among MRI participants, 96% completed all 12 MRI sequences. More than 90% of the participants agreed to the use of complementary secondary and registry data. Individuals selected for the NAKO were willing to participate in all examinations despite the time-consuming program. The NAKO provides a central resource for population-based epidemiologic research and will contribute to developing innovative strategies for prevention, screening and prediction of chronic diseases.
Author Michels, Karin B
Rach, Stefan
Schmidt, Börge
Berger, Klaus
Meinke-Franze, Claudia
Swart, Enno
Kurth, Bärbel
Greiser, Karin H
Pischon, Tobias
Damms-Machado, Antje
Stübs, Gunthard
Leitzmann, Michael
Schikowski, Tamara
Peters, Annette
Lieb, Wolfgang
Schöne, Gina
Kauczor, Hans-Ulrich
Franzke, Claus-Werner
Günther, Kathrin
Löffler, Markus
Linseisen, Jakob
Becher, Heiko
Kuß, Oliver
Hoffmann, Wolfgang
Mikolajczyk, Rafael
Kaaks, Rudolf
Stallmann, Christoph
Schulze, Matthias B
Völzke, Henry
Castell, Stefanie
Gastell, Sylvia
Mueller, Ulrich
Pigeot, Iris
Legath, Nicole
Schipf, Sabine
Kluttig, Alexander
Fischer, Beate
Jagodzinski, Annika
Ahrens, Wolfgang
Brenner, Hermann
Fricke, Julia
Krist, Lilian
Holleczek, Bernd
Wirkner, Kerstin
Waniek, Sabine
Bamberg, Fabian
Günther, Matthias
Jöckel, Karl-Heinz
Kemmling, Yvonne
Stang, Andreas
Jaeschke, Lina
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  givenname: Heiko
  surname: Becher
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  organization: Institut für Medizinische Biometrie und Epidemiologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg-Eppendorf, Deutschland
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  givenname: Klaus
  surname: Berger
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  givenname: Hermann
  surname: Brenner
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  surname: Castell
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  givenname: Antje
  surname: Damms-Machado
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– sequence: 14
  givenname: Beate
  surname: Fischer
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  givenname: Claus-Werner
  surname: Franzke
  fullname: Franzke, Claus-Werner
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– sequence: 16
  givenname: Julia
  surname: Fricke
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– sequence: 17
  givenname: Sylvia
  surname: Gastell
  fullname: Gastell, Sylvia
  organization: NAKO Studienzentrum, Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke, Nuthetal, Deutschland
– sequence: 18
  givenname: Matthias
  surname: Günther
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  organization: Fraunhofer MEVIS-Institut for Medical Image Computing, Bremen, German Faculty of Physics and Electronics, University of Bremen, Bremen, Deutschland
– sequence: 19
  givenname: Wolfgang
  surname: Hoffmann
  fullname: Hoffmann, Wolfgang
  organization: Institut für Community Medicine, Abteilung für Versorgungsepidemiologie und Community Health, Universitätsmedizin Greifswald, Walther-Rathenau-Str. 48, 17489, Greifswald, Deutschland
– sequence: 20
  givenname: Bernd
  surname: Holleczek
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  givenname: Karl-Heinz
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  surname: Krist
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  givenname: Markus
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  givenname: Karin B
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  givenname: Iris
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  givenname: Ulrich
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  givenname: Stefan
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/32047976$$D View this record in MEDLINE/PubMed
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DocumentTitleAlternate Die Basiserhebung der NAKO Gesundheitsstudie: Teilnahme an den Untersuchungsmodulen, Qualitätssicherung und Nutzung von Sekundärdaten
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Germany
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Humans
Male
Middle Aged
Registries
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Title The baseline assessment of the German National Cohort (NAKO Gesundheitsstudie): participation in the examination modules, quality assurance, and the use of secondary data
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