Severe systemic lupus erythematosus induced by isoniazide

The authors report a rare case of low register systemic lupus erythematosus with renal attack and neurological armature by isoniazid. The patient was a 23-year-old woman presenting a lupus induced by isoniazid 1 month after the treatment of pleural tuberculosis. Antinuclear antibodies, anti-native D...

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Vydáno v:	Revue de pneumologie clinique Ročník 65; číslo 6; s. 361
Hlavní autoři:	Rakotoson, J L, Randriamanana, D, Rakotomizao, J R, Andrianasolo, R, Rakotoarivelo, R, Andrianarisoa, A C F
Médium:	Journal Article
Jazyk:	francouzština
Vydáno:	France 01.12.2009
Témata:	Anti-Inflammatory Agents - therapeutic use Antibodies, Antinuclear - blood Antitubercular Agents - adverse effects Antitubercular Agents - therapeutic use Drug Therapy, Combination Female Humans Isoniazid - adverse effects Isoniazid - therapeutic use Lupus Erythematosus, Systemic - chemically induced Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - drug therapy Lupus Nephritis - chemically induced Lupus Nephritis - diagnosis Lupus Nephritis - drug therapy Madagascar Methylprednisolone - therapeutic use Tuberculosis, Pleural - drug therapy Young Adult Madagascar
ISSN:	0761-8417, 1776-2561, 1776-2561
On-line přístup:	Získat plný text
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Shrnutí:	The authors report a rare case of low register systemic lupus erythematosus with renal attack and neurological armature by isoniazid. The patient was a 23-year-old woman presenting a lupus induced by isoniazid 1 month after the treatment of pleural tuberculosis. Antinuclear antibodies, anti-native DNA, anti-ENA, anti-Sm, anti-SSa, anti-SSb and antihistone were present. The symptoms included arthralgia, fever, anaemia, pleural effusion, pericarditis and anasarca. She presented a renal and neurological attack, accounting for the gravity of the disease. The treatment consisted of the interruption of the isoniazid and a bolus of methyl-prednisolone during 3 days relayed by an oral corticosteroid. The evolution was favourable after 8 months of corticosteroids.
Bibliografie:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Article-4 ObjectType-Report-1
ISSN:	0761-8417 1776-2561 1776-2561
DOI:	10.1016/j.pneumo.2009.08.006