Severe systemic lupus erythematosus induced by isoniazide

The authors report a rare case of low register systemic lupus erythematosus with renal attack and neurological armature by isoniazid. The patient was a 23-year-old woman presenting a lupus induced by isoniazid 1 month after the treatment of pleural tuberculosis. Antinuclear antibodies, anti-native D...

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Bibliographic Details
Published in:Revue de pneumologie clinique Vol. 65; no. 6; p. 361
Main Authors: Rakotoson, J L, Randriamanana, D, Rakotomizao, J R, Andrianasolo, R, Rakotoarivelo, R, Andrianarisoa, A C F
Format: Journal Article
Language:French
Published: France 01.12.2009
Subjects:
Anti-Inflammatory Agents - therapeutic use
Antibodies, Antinuclear - blood
Antitubercular Agents - adverse effects
Antitubercular Agents - therapeutic use
Drug Therapy, Combination
Female
Humans
Isoniazid - adverse effects
Isoniazid - therapeutic use
Lupus Erythematosus, Systemic - chemically induced
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - drug therapy
Lupus Nephritis - chemically induced
Lupus Nephritis - diagnosis
Lupus Nephritis - drug therapy
Madagascar
Methylprednisolone - therapeutic use
Tuberculosis, Pleural - drug therapy
Young Adult
Madagascar
ISSN:0761-8417, 1776-2561, 1776-2561
Online Access:Get full text
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Summary:The authors report a rare case of low register systemic lupus erythematosus with renal attack and neurological armature by isoniazid. The patient was a 23-year-old woman presenting a lupus induced by isoniazid 1 month after the treatment of pleural tuberculosis. Antinuclear antibodies, anti-native DNA, anti-ENA, anti-Sm, anti-SSa, anti-SSb and antihistone were present. The symptoms included arthralgia, fever, anaemia, pleural effusion, pericarditis and anasarca. She presented a renal and neurological attack, accounting for the gravity of the disease. The treatment consisted of the interruption of the isoniazid and a bolus of methyl-prednisolone during 3 days relayed by an oral corticosteroid. The evolution was favourable after 8 months of corticosteroids.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0761-8417
1776-2561
1776-2561
DOI:10.1016/j.pneumo.2009.08.006