Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgV(H) status and immunophenotyping

In CLL data from chromosome banding analysis (CBA) have been scarce due to the low proliferative activity of CLL cells in vitro. We improved the cultivation technique using an immunostimulatory CpG-oligonucleotide DSP30 and IL-2. A total of 506 CLL samples were analysed with CBA and interphase FISH...

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Bibliographic Details
Published in:	Leukemia Vol. 21; no. 12; p. 2442
Main Authors:	Haferlach, C, Dicker, F, Schnittger, S, Kern, W, Haferlach, T
Format:	Journal Article
Language:	English
Published:	England 01.12.2007
Subjects:	ADP-ribosyl Cyclase 1 - biosynthesis ADP-ribosyl Cyclase 1 - genetics Adult Aged Aged, 80 and over Cell Culture Techniques - methods Chromosome Aberrations Chromosome Banding Female Gene Expression Profiling Gene Expression Regulation, Leukemic Gene Rearrangement, B-Lymphocyte, Heavy Chain Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - genetics Immunophenotyping In Situ Hybridization, Fluorescence Interleukin-2 - pharmacology Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Male Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Middle Aged Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism Tumor Cells, Cultured - ultrastructure ZAP-70 Protein-Tyrosine Kinase - biosynthesis ZAP-70 Protein-Tyrosine Kinase - genetics
ISSN:	1476-5551, 1476-5551
Online Access:	Get full text
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