Nuclear transfer and reprogramming in fish

As an important sub-field in the study of animal cloning, fish nuclear transfer was first established in the early 1960s by Chinese embryologists. Due to its advantages, zebrafish has become a unique animal model to study the mystery of reprogramming in nuclear transfer. This article summarizes the...

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Bibliographic Details
Published in:	Yíchuán Vol. 35; no. 4; p. 433
Main Authors:	Wang, Xue-Geng, Zhu, Zuo-Yan, Sun, Yong-Hua, Zhao, Jue
Format:	Journal Article
Language:	Chinese
Published:	China 01.04.2013
Subjects:	Animals Cellular Reprogramming Embryo, Nonmammalian - embryology Embryo, Nonmammalian - metabolism Nuclear Transfer Techniques Zebrafish - embryology Zebrafish - genetics
ISSN:	0253-9772
Online Access:	Get more information
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Summary:	As an important sub-field in the study of animal cloning, fish nuclear transfer was first established in the early 1960s by Chinese embryologists. Due to its advantages, zebrafish has become a unique animal model to study the mystery of reprogramming in nuclear transfer. This article summarizes the history and current situation in fish nuclear transfer technology and discusses the factors that may influence the development of the cloned embryos. A comprehensive understand-ing of the mechanism for epigenetic modification following nuclear transfer, such as genomic DNA methylation and histone acetylation and/or methylation, will likely increase the success rate and eventually lead to the future freedom of cloning technique.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23
ISSN:	0253-9772
DOI:	10.3724/SP.J.1005.2013.00433