Photogenerator of trichloroacetic acid--a perspective detritylation agent for microchip oligonucleotide synthesis

For the purpose of new detritylation agents search for microarray oligonucleotide synthesis we investigated applicability of [4-(4-methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate for 4,4'-dimethoxytrityl group detritylation during oligonucleotide syntheses generating tri...

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Vydané v:Bioorganicheskaia khimiia Ročník 40; číslo 5; s. 636
Hlavní autori: Siniakov, A N, Nikolaenkova, E B, Os'kina, I A, Savel'ev, V A, Samsonov, V A, Tikhonov, A Ia, Palatkina, M Iu, Zaĭtsev, D E
Médium: Journal Article
Jazyk:Russian
Vydavateľské údaje: Russia (Federation) 01.09.2014
Predmet:
Kinetics
Light
Microchip Analytical Procedures
Molecular Structure
Oligonucleotides - chemical synthesis
Oligonucleotides - chemistry
Trichloroacetic Acid - chemical synthesis
Trichloroacetic Acid - chemistry
ISSN:0132-3423
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Shrnutí:For the purpose of new detritylation agents search for microarray oligonucleotide synthesis we investigated applicability of [4-(4-methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate for 4,4'-dimethoxytrityl group detritylation during oligonucleotide syntheses generating trichloroacetic acid at radiation by light with a length of wave of 405 nanometers. [4-(4-Methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate has been successfully used for solid-phase oligonucleotide synthesis of desired oligonucleotides.
Bibliografia:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0132-3423
DOI:10.7868/s0132342314050121