Photogenerator of trichloroacetic acid--a perspective detritylation agent for microchip oligonucleotide synthesis

For the purpose of new detritylation agents search for microarray oligonucleotide synthesis we investigated applicability of [4-(4-methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate for 4,4'-dimethoxytrityl group detritylation during oligonucleotide syntheses generating tri...

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Veröffentlicht in:Bioorganicheskaia khimiia Jg. 40; H. 5; S. 636
Hauptverfasser: Siniakov, A N, Nikolaenkova, E B, Os'kina, I A, Savel'ev, V A, Samsonov, V A, Tikhonov, A Ia, Palatkina, M Iu, Zaĭtsev, D E
Format: Journal Article
Sprache:Russisch
Veröffentlicht: Russia (Federation) 01.09.2014
Schlagworte:
Kinetics
Light
Microchip Analytical Procedures
Molecular Structure
Oligonucleotides - chemical synthesis
Oligonucleotides - chemistry
Trichloroacetic Acid - chemical synthesis
Trichloroacetic Acid - chemistry
ISSN:0132-3423
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Abstract For the purpose of new detritylation agents search for microarray oligonucleotide synthesis we investigated applicability of [4-(4-methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate for 4,4'-dimethoxytrityl group detritylation during oligonucleotide syntheses generating trichloroacetic acid at radiation by light with a length of wave of 405 nanometers. [4-(4-Methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate has been successfully used for solid-phase oligonucleotide synthesis of desired oligonucleotides.
AbstractList For the purpose of new detritylation agents search for microarray oligonucleotide synthesis we investigated applicability of [4-(4-methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate for 4,4'-dimethoxytrityl group detritylation during oligonucleotide syntheses generating trichloroacetic acid at radiation by light with a length of wave of 405 nanometers. [4-(4-Methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate has been successfully used for solid-phase oligonucleotide synthesis of desired oligonucleotides.
For the purpose of new detritylation agents search for microarray oligonucleotide synthesis we investigated applicability of [4-(4-methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate for 4,4'-dimethoxytrityl group detritylation during oligonucleotide syntheses generating trichloroacetic acid at radiation by light with a length of wave of 405 nanometers. [4-(4-Methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate has been successfully used for solid-phase oligonucleotide synthesis of desired oligonucleotides.For the purpose of new detritylation agents search for microarray oligonucleotide synthesis we investigated applicability of [4-(4-methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate for 4,4'-dimethoxytrityl group detritylation during oligonucleotide syntheses generating trichloroacetic acid at radiation by light with a length of wave of 405 nanometers. [4-(4-Methoxyphenyl)-2,6-dinitro-phenyl](phenyl)methyl 2,2,2-trichloroacetate has been successfully used for solid-phase oligonucleotide synthesis of desired oligonucleotides.
Author Os'kina, I A
Savel'ev, V A
Zaĭtsev, D E
Nikolaenkova, E B
Tikhonov, A Ia
Samsonov, V A
Siniakov, A N
Palatkina, M Iu
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SubjectTerms Kinetics
Light
Microchip Analytical Procedures
Molecular Structure
Oligonucleotides - chemical synthesis
Oligonucleotides - chemistry
Trichloroacetic Acid - chemical synthesis
Trichloroacetic Acid - chemistry
Title Photogenerator of trichloroacetic acid--a perspective detritylation agent for microchip oligonucleotide synthesis
URI https://www.ncbi.nlm.nih.gov/pubmed/25895359
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