Ca(2+) coding and decoding strategies for the specification of neural and renal precursor cells during development

During embryogenesis, a rise in intracellular Ca(2+) is known to be a widespread trigger for directing stem cells towards a specific tissue fate, but the precise Ca(2+) signalling mechanisms involved in achieving these pleiotropic effects are still poorly understood. In this review, we compare the C...

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Published in:Cell calcium (Edinburgh) Vol. 59; no. 2-3; pp. 75 - 83
Main Authors: Moreau, Marc, Néant, Isabelle, Webb, Sarah E, Miller, Andrew L, Riou, Jean-François, Leclerc, Catherine
Format: Journal Article
Language:English
Published: Netherlands 01.03.2016
Subjects:
Animals
Calcium - metabolism
Calcium Signaling
Humans
Kidney - cytology
Kidney - embryology
Kidney - metabolism
Neural Stem Cells - cytology
Neural Stem Cells - metabolism
Neurogenesis
Stem Cells - cytology
Stem Cells - metabolism
Calcium signalling
Kcnip
TRPP channel
Neural induction
Calcium-dependent transcription
Pronephros specification
Renal precursors
Cav1.2 channel
Neural progenitors
ISSN:1532-1991
Online Access:Get full text
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Abstract During embryogenesis, a rise in intracellular Ca(2+) is known to be a widespread trigger for directing stem cells towards a specific tissue fate, but the precise Ca(2+) signalling mechanisms involved in achieving these pleiotropic effects are still poorly understood. In this review, we compare the Ca(2+) signalling events that appear to be one of the first steps in initiating and regulating both neural determination (neural induction) and kidney development (nephrogenesis). We have highlighted the necessary and sufficient role played by Ca(2+) influx and by Ca(2+) transients in the determination and differentiation of pools of neural or renal precursors. We have identified new Ca(2+) target genes involved in neural induction and we showed that the same Ca(2+) early target genes studied are not restricted to neural tissue but are also present in other tissues, principally in the pronephros. In this review, we also described a mechanism whereby the transcriptional control of gene expression during neurogenesis and nephrogenesis might be directly controlled by Ca(2+) signalling. This mechanism involves members of the Kcnip family such that a change in their binding properties to specific DNA sites is a result of Ca(2+) binding to EF-hand motifs. The different functions of Ca(2+) signalling during these two events illustrate the versatility of Ca(2+) as a second messenger.
AbstractList During embryogenesis, a rise in intracellular Ca(2+) is known to be a widespread trigger for directing stem cells towards a specific tissue fate, but the precise Ca(2+) signalling mechanisms involved in achieving these pleiotropic effects are still poorly understood. In this review, we compare the Ca(2+) signalling events that appear to be one of the first steps in initiating and regulating both neural determination (neural induction) and kidney development (nephrogenesis). We have highlighted the necessary and sufficient role played by Ca(2+) influx and by Ca(2+) transients in the determination and differentiation of pools of neural or renal precursors. We have identified new Ca(2+) target genes involved in neural induction and we showed that the same Ca(2+) early target genes studied are not restricted to neural tissue but are also present in other tissues, principally in the pronephros. In this review, we also described a mechanism whereby the transcriptional control of gene expression during neurogenesis and nephrogenesis might be directly controlled by Ca(2+) signalling. This mechanism involves members of the Kcnip family such that a change in their binding properties to specific DNA sites is a result of Ca(2+) binding to EF-hand motifs. The different functions of Ca(2+) signalling during these two events illustrate the versatility of Ca(2+) as a second messenger.
Author Leclerc, Catherine
Webb, Sarah E
Riou, Jean-François
Miller, Andrew L
Moreau, Marc
Néant, Isabelle
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  givenname: Isabelle
  surname: Néant
  fullname: Néant, Isabelle
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  givenname: Andrew L
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  givenname: Jean-François
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  givenname: Catherine
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  organization: Université Toulouse 3, Centre de Biologie du Développement, 118 route de Narbonne, F31062 Toulouse Cedex 04, France; CNRS UMR5547, Toulouse F31062, France. Electronic address: catherine.leclerc@univ-tlse3.fr
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Keywords Calcium signalling
Kcnip
TRPP channel
Neural induction
Calcium-dependent transcription
Pronephros specification
Renal precursors
Cav1.2 channel
Neural progenitors
Language English
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SubjectTerms Animals
Calcium - metabolism
Calcium Signaling
Humans
Kidney - cytology
Kidney - embryology
Kidney - metabolism
Neural Stem Cells - cytology
Neural Stem Cells - metabolism
Neurogenesis
Stem Cells - cytology
Stem Cells - metabolism
Title Ca(2+) coding and decoding strategies for the specification of neural and renal precursor cells during development
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