Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme

Glioblastoma multiforme is the most malignant tumor of the brain and is challenging to treat due to its highly invasive nature and heterogeneity. Malignant brain tumor displays high metabolic activity which perturbs its redox environment and in turn translates to high oxidative stress. Thus, pushing...

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Veröffentlicht in:	Stem cell reviews and reports Jg. 12; H. 1; S. 140
Hauptverfasser:	Yulyana, Yulyana, Tovmasyan, Artak, Ho, Ivy A W, Sia, Kian Chuan, Newman, Jennifer P, Ng, Wai Hoe, Guo, Chang Ming, Hui, Kam Man, Batinic-Haberle, Ines, Lam, Paula Y P
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.02.2016
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Ascorbic Acid - agonists Ascorbic Acid - biosynthesis Astrocytes - cytology Astrocytes - drug effects Biomimetic Materials - chemical synthesis Biomimetic Materials - pharmacology Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Carbenoxolone - pharmacology Cell Line Cell Line, Tumor Cell Survival - drug effects Drug Combinations Drug Resistance, Neoplasm - drug effects Drug Synergism Gap Junctions - drug effects Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Humans Hydrogen Peroxide - agonists Hydrogen Peroxide - metabolism Metalloporphyrins - chemical synthesis Metalloporphyrins - pharmacology Organ Specificity Oxidative Stress Primary Cell Culture Sulfhydryl Compounds - agonists Sulfhydryl Compounds - metabolism Superoxide Dismutase - chemistry TNF-Related Apoptosis-Inducing Ligand - pharmacology Carbenoxolone NAC SOD mimic Manganese porphyrin Glioma TRAIL-modified human mesenchymal stem cells Ascorbate
ISSN:	2629-3277, 2629-3277
Online-Zugang:	Volltext
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