Oral controlled-release oxycodone for uterine cramping pain after cesarean section
To evaluate whether combined oral oxycodone hydrochloride controlled-release tablets plus paracetamol and tramadol hydrochloride tablets is better than epidural analgesia with respect to uterine cramping pain control and side effects after cesarean section. Sixty consecutive patients scheduled for c...
Gespeichert in:
| Veröffentlicht in: | Zhong hua yi xue za zhi Jg. 91; H. 30; S. 2132 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Chinesisch |
| Veröffentlicht: |
China
16.08.2011
|
| Schlagworte: | |
| ISSN: | 0376-2491 |
| Online-Zugang: | Weitere Angaben |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | To evaluate whether combined oral oxycodone hydrochloride controlled-release tablets plus paracetamol and tramadol hydrochloride tablets is better than epidural analgesia with respect to uterine cramping pain control and side effects after cesarean section.
Sixty consecutive patients scheduled for cesarean section from April to May, 2010 were randomized to either patient-controlled epidural analgesia with 0.1% ropivacaine, 0.1 µg/ml sufentanil (for postoperative 48 h) plus injected pethidine on demand (EDA group) or controlled-release oxycodone (2 × 15 mg for 1st postoperative 24 h; 2 × 10 mg for 2nd postoperative 24 h), paracetamol & tramadol hydrochloride tablets (8 × 1 tablet for postoperative 48 h) orally plus pethidine injection on demand (OXY group). Two groups were compared with respects to uterine cramping pain control when the oxytocin infusion (20 U plus 500 ml 5% glucose solution, iv. gtt within 2 h) once per day for postoperative 3 days as determined by the means of a visual analogue scale (VAS), pethidine consumption, side effects and costs.
The EDA group experienced significant more pain than the OXY group when the oxytocin infusion was administered (mm) [50.0 (15.0, 72.5) vs 25.0 (0, 40.0), 60.0 (47.5, 72.5) vs 20.0 (0, 30.0), 35.0 (20.0, 50.0) vs 0 (0, 20.0)]. all P < 0.05). Pethidine was used for pain control in 2 patients (150 mg total) of EDA group during the oxytocin infusion whereas none of the OXY group received an injection of pethidine. There was a higher level of maternal satisfaction with a lower analgesic dose in the EDA group (80.9 ± 9.3 vs 90.0 ± 9.8, P < 0.01). The median duration of hospital stay was around 5 days in both groups.
Postoperative pain control after cesarean section with the above combined regimen is superior to EDA in terms of a lower cost and a higher level of maternal satisfaction. |
|---|---|
| AbstractList | To evaluate whether combined oral oxycodone hydrochloride controlled-release tablets plus paracetamol and tramadol hydrochloride tablets is better than epidural analgesia with respect to uterine cramping pain control and side effects after cesarean section.OBJECTIVETo evaluate whether combined oral oxycodone hydrochloride controlled-release tablets plus paracetamol and tramadol hydrochloride tablets is better than epidural analgesia with respect to uterine cramping pain control and side effects after cesarean section.Sixty consecutive patients scheduled for cesarean section from April to May, 2010 were randomized to either patient-controlled epidural analgesia with 0.1% ropivacaine, 0.1 µg/ml sufentanil (for postoperative 48 h) plus injected pethidine on demand (EDA group) or controlled-release oxycodone (2 × 15 mg for 1st postoperative 24 h; 2 × 10 mg for 2nd postoperative 24 h), paracetamol & tramadol hydrochloride tablets (8 × 1 tablet for postoperative 48 h) orally plus pethidine injection on demand (OXY group). Two groups were compared with respects to uterine cramping pain control when the oxytocin infusion (20 U plus 500 ml 5% glucose solution, iv. gtt within 2 h) once per day for postoperative 3 days as determined by the means of a visual analogue scale (VAS), pethidine consumption, side effects and costs.METHODSSixty consecutive patients scheduled for cesarean section from April to May, 2010 were randomized to either patient-controlled epidural analgesia with 0.1% ropivacaine, 0.1 µg/ml sufentanil (for postoperative 48 h) plus injected pethidine on demand (EDA group) or controlled-release oxycodone (2 × 15 mg for 1st postoperative 24 h; 2 × 10 mg for 2nd postoperative 24 h), paracetamol & tramadol hydrochloride tablets (8 × 1 tablet for postoperative 48 h) orally plus pethidine injection on demand (OXY group). Two groups were compared with respects to uterine cramping pain control when the oxytocin infusion (20 U plus 500 ml 5% glucose solution, iv. gtt within 2 h) once per day for postoperative 3 days as determined by the means of a visual analogue scale (VAS), pethidine consumption, side effects and costs.The EDA group experienced significant more pain than the OXY group when the oxytocin infusion was administered (mm) [50.0 (15.0, 72.5) vs 25.0 (0, 40.0), 60.0 (47.5, 72.5) vs 20.0 (0, 30.0), 35.0 (20.0, 50.0) vs 0 (0, 20.0)]. all P < 0.05). Pethidine was used for pain control in 2 patients (150 mg total) of EDA group during the oxytocin infusion whereas none of the OXY group received an injection of pethidine. There was a higher level of maternal satisfaction with a lower analgesic dose in the EDA group (80.9 ± 9.3 vs 90.0 ± 9.8, P < 0.01). The median duration of hospital stay was around 5 days in both groups.RESULTSThe EDA group experienced significant more pain than the OXY group when the oxytocin infusion was administered (mm) [50.0 (15.0, 72.5) vs 25.0 (0, 40.0), 60.0 (47.5, 72.5) vs 20.0 (0, 30.0), 35.0 (20.0, 50.0) vs 0 (0, 20.0)]. all P < 0.05). Pethidine was used for pain control in 2 patients (150 mg total) of EDA group during the oxytocin infusion whereas none of the OXY group received an injection of pethidine. There was a higher level of maternal satisfaction with a lower analgesic dose in the EDA group (80.9 ± 9.3 vs 90.0 ± 9.8, P < 0.01). The median duration of hospital stay was around 5 days in both groups.Postoperative pain control after cesarean section with the above combined regimen is superior to EDA in terms of a lower cost and a higher level of maternal satisfaction.CONCLUSIONPostoperative pain control after cesarean section with the above combined regimen is superior to EDA in terms of a lower cost and a higher level of maternal satisfaction. To evaluate whether combined oral oxycodone hydrochloride controlled-release tablets plus paracetamol and tramadol hydrochloride tablets is better than epidural analgesia with respect to uterine cramping pain control and side effects after cesarean section. Sixty consecutive patients scheduled for cesarean section from April to May, 2010 were randomized to either patient-controlled epidural analgesia with 0.1% ropivacaine, 0.1 µg/ml sufentanil (for postoperative 48 h) plus injected pethidine on demand (EDA group) or controlled-release oxycodone (2 × 15 mg for 1st postoperative 24 h; 2 × 10 mg for 2nd postoperative 24 h), paracetamol & tramadol hydrochloride tablets (8 × 1 tablet for postoperative 48 h) orally plus pethidine injection on demand (OXY group). Two groups were compared with respects to uterine cramping pain control when the oxytocin infusion (20 U plus 500 ml 5% glucose solution, iv. gtt within 2 h) once per day for postoperative 3 days as determined by the means of a visual analogue scale (VAS), pethidine consumption, side effects and costs. The EDA group experienced significant more pain than the OXY group when the oxytocin infusion was administered (mm) [50.0 (15.0, 72.5) vs 25.0 (0, 40.0), 60.0 (47.5, 72.5) vs 20.0 (0, 30.0), 35.0 (20.0, 50.0) vs 0 (0, 20.0)]. all P < 0.05). Pethidine was used for pain control in 2 patients (150 mg total) of EDA group during the oxytocin infusion whereas none of the OXY group received an injection of pethidine. There was a higher level of maternal satisfaction with a lower analgesic dose in the EDA group (80.9 ± 9.3 vs 90.0 ± 9.8, P < 0.01). The median duration of hospital stay was around 5 days in both groups. Postoperative pain control after cesarean section with the above combined regimen is superior to EDA in terms of a lower cost and a higher level of maternal satisfaction. |
| Author | Liu, Qin Zhao, Jin-ning Chen, Hui-xiang Zhong, Tai-di |
| Author_xml | – sequence: 1 givenname: Qin surname: Liu fullname: Liu, Qin organization: Department of Anesthesiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University Institute of Clinical Medicine, Sir Run Run Shaw, Zhejiang University, Hangzhou 310016, China – sequence: 2 givenname: Jin-ning surname: Zhao fullname: Zhao, Jin-ning – sequence: 3 givenname: Hui-xiang surname: Chen fullname: Chen, Hui-xiang – sequence: 4 givenname: Tai-di surname: Zhong fullname: Zhong, Tai-di |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22093991$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1kE1LxDAYhHNYcdd1_4Lk5qmQpB9pjrL4BQsLoufyJnkjgTSpSQvuv7egnmaYeZjD3JBNTBE3ZMdq2VWiUXxLDqV4zRpZK8EEvyZbIZiqleI78nbOEKhJcc4pBLRVxoBQkKbvi0l2naIuZbrMmP3qTYZx8vGTTuAjBbfG1GCBjBBpQTP7FG_JlYNQ8PCne_Lx9Ph-fKlO5-fX48Opmrho58pYxpRt6071jbWtNRxdD04aZSUqyXlbG70WUkPPZG-lkT1o6Rquu8bpXuzJ_e_ulNPXgmUeRl8MhgAR01IGxdpO1i3vVvLuj1z0iHaYsh8hX4b_G8QP6DdcfA |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| ExternalDocumentID | 22093991 |
| Genre | Randomized Controlled Trial English Abstract Journal Article |
| GroupedDBID | --- -05 92F 92I ABJNI ACGFS ALMA_UNASSIGNED_HOLDINGS CCEZO CGR CIEJG CUY CVF CW9 ECM EIF F5P NPM TCJ TGQ U5O W2D 7X8 U1G |
| ID | FETCH-LOGICAL-p125t-cd009d536984dd5dc1ef8af7c9d7e971153cbdd57ba8078d7c78ab7f41b64fb82 |
| IEDL.DBID | 7X8 |
| ISSN | 0376-2491 |
| IngestDate | Sun Sep 28 08:16:41 EDT 2025 Thu Apr 03 07:01:56 EDT 2025 |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 30 |
| Language | Chinese |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-p125t-cd009d536984dd5dc1ef8af7c9d7e971153cbdd57ba8078d7c78ab7f41b64fb82 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 |
| PMID | 22093991 |
| PQID | 905673516 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_905673516 pubmed_primary_22093991 |
| PublicationCentury | 2000 |
| PublicationDate | 2011-Aug-16 20110816 |
| PublicationDateYYYYMMDD | 2011-08-16 |
| PublicationDate_xml | – month: 08 year: 2011 text: 2011-Aug-16 day: 16 |
| PublicationDecade | 2010 |
| PublicationPlace | China |
| PublicationPlace_xml | – name: China |
| PublicationTitle | Zhong hua yi xue za zhi |
| PublicationTitleAlternate | Zhonghua Yi Xue Za Zhi |
| PublicationYear | 2011 |
| SSID | ssib047392021 ssj0042171 ssib023169068 ssib001522033 ssib021435496 ssib001103465 ssib004213762 ssib046626340 ssib051368196 ssib058575311 |
| Score | 1.7885491 |
| Snippet | To evaluate whether combined oral oxycodone hydrochloride controlled-release tablets plus paracetamol and tramadol hydrochloride tablets is better than... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 2132 |
| SubjectTerms | Adult Analgesia, Obstetrical - methods Analgesia, Patient-Controlled Cesarean Section Female Humans Oxycodone - administration & dosage Oxycodone - therapeutic use Pain, Postoperative - drug therapy |
| Title | Oral controlled-release oxycodone for uterine cramping pain after cesarean section |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/22093991 https://www.proquest.com/docview/905673516 |
| Volume | 91 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV07T8MwELaAIsTC-1Fe8sBqEceOHxNCCMTSUiGQulV-JKISpKEpCPj1nNM07YIYWLI4jqPL-e473-U-hM6pjYVSYP2o1RCgeK6JTSwjjjpvVBZZ66KKbEJ2u6rf1726NqesyypnNrEy1H7kwhn5hQZPLVlCxWXxRgJpVEiu1gway6jFAMkEpZb9hSQQjRgXi93I4ngxacdjCtur8e5xgA583n0OkE_o4ts8j4vQuWXeGoVLwBbR3PsllAnwr838JJBfMtpUnMByVfwXwaIEoh76O6itnNvt5j_FsoU2alSLr6ZquI2Wvp930Fqnztvvoof7MQzXZfEvqSeBqgX8Jx59fjkIjPMUA3jGgV4C7sdubF7Df1y4MMMcVzTmGOyZAYCb47IqHsv30NPtzeP1HanZHEgBIGpCnAc45xMmtOLeJ97RNFMmk057mWoJyJQ5CwPSmtAD30snlbEy49QKnlkV76OVHN7nEGFnhKUshVDOh7wjs84k3jCvZSQMfPI2wjNhDWC3hBSIydPRezloxNVGB1OBD4ppV48B6IYGHaJHf08-Ruuzo2UqTlArA0uRnqJV9zEZluOzSgvh2u11fgCh_tw3 |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Oral+controlled-release+oxycodone+for+uterine+cramping+pain+after+cesarean+section&rft.jtitle=Zhong+hua+yi+xue+za+zhi&rft.au=Liu%2C+Qin&rft.au=Zhao%2C+Jin-ning&rft.au=Chen%2C+Hui-xiang&rft.au=Zhong%2C+Tai-di&rft.date=2011-08-16&rft.issn=0376-2491&rft.volume=91&rft.issue=30&rft.spage=2132&rft_id=info%3Apmid%2F22093991&rft_id=info%3Apmid%2F22093991&rft.externalDocID=22093991 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0376-2491&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0376-2491&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0376-2491&client=summon |