Efficacy of an experimental dentifrice formulation on primary school children in Ga-Rankuwa, Pretoria

The purpose of this study was to assess the efficacy of a dentifrice containing 1 per cent chlorhexidine gluconate at reducing plaque formation and gingival inflammation over a 12 week period. The effects of the test toothpaste were compared with control and conventional dentifrices in a randomised...

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Bibliographic Details
Published in:The Journal of the Dental Association of South Africa = Die Tydskrif van die Tandheelkundige Vereniging van Suid-Afrika Vol. 49; no. 5; p. 209
Main Authors: Gugushe, T S, de Wet, F A, Rojas-Silva, O
Format: Journal Article
Language:English
Published: South Africa 01.05.1994
Subjects:
Adolescent
Child
Chlorhexidine - analogs & derivatives
Chlorhexidine - therapeutic use
Dental Plaque - prevention & control
Dental Plaque Index
Dentifrices - therapeutic use
Double-Blind Method
Female
Gingivitis - prevention & control
Humans
Male
Periodontal Index
South Africa
Time Factors
Toothpastes - therapeutic use
South Africa
ISSN:0011-8516
Online Access:Get more information
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Summary:The purpose of this study was to assess the efficacy of a dentifrice containing 1 per cent chlorhexidine gluconate at reducing plaque formation and gingival inflammation over a 12 week period. The effects of the test toothpaste were compared with control and conventional dentifrices in a randomised double-blind clinical trial of parallel design. Following baseline examination at which gingival and plaque indices (GI and PI) were measured, 156 primary school children were assigned to one of three groups that were matched for age, gender, GI and PI. After plaque control instruction the pupils were requested to use the dentifrice twice daily. After 6 and 12 week intervals the PI and GI were reassessed. There was no significant difference in GI between groups. The PI was significantly lower (p < 0.002) after use of the chlorhexidine containing dentifrice compared with the other two products.
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ISSN:0011-8516