Ninety-day experimental hyperthyroidism in male rats: Effects on muscle contractility, fiber composition, oxidative stress, and nerve conduction

Hyperthyroidism generates a hypermetabolic state that promotes adaptations in the skeletal muscle and peripheral nerves leading to deleterious effects. However, there is a paucity of data and conflicting evidence on the influence of thyroid hormones on muscles with predominantly glycolytic fibers an...

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Bibliographic Details
Published in:	Physiological reports Vol. 13; no. 23; p. e70669
Main Authors:	Peixoto, João Victor Capelli, Ferrari, Marcelo Cardoso, Lourenço, Sarah Lethícia, Zazula, Matheus Felipe, Stipp, Maria Carolina, Beltrame, Olair Carlos, Acco, Alexandra, Naliwaiko, Katya, Dias, Fernando Augusto Lavezzo, Fogaça, Rosalvo Tadeu Hochmueller
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01.12.2025
Subjects:	Action potential Animal models Animals Antioxidants Atrophy Catalase - metabolism Diaphragm Diaphragm - metabolism Diaphragm - physiopathology Fatigue Glycolysis Hormones Hyperthyroidism Hyperthyroidism - chemically induced Hyperthyroidism - metabolism Hyperthyroidism - physiopathology Immunoassay Kinases Laboratory animals Latency Male Metabolism Muscle contraction Muscle Contraction - physiology Muscle Fatigue Muscle Fibers, Skeletal - metabolism Muscle Fibers, Skeletal - physiology Muscle, Skeletal - metabolism Muscle, Skeletal - physiopathology Musculoskeletal system Nerve conduction Neural Conduction - physiology Oxidative Stress Peripheral nerves Plasma Proteins Rats Rats, Wistar Sciatic nerve Sciatic Nerve - metabolism Sciatic Nerve - physiopathology Skeletal muscle Superoxide dismutase Superoxide Dismutase - metabolism Thyroid gland Thyroid hormones Thyroxine Brazil fiber type diaphragm hyperthyroidism EDL oxidative stress rodents
ISSN:	2051-817X, 2051-817X
Online Access:	Get full text
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