The RNA modification N 6 -methyladenosine as a novel regulator of the immune system

Protection from harmful pathogens depends on activation of the immune system, which relies on tight regulation of gene expression. Recently, the RNA modification N -methyladenosine (m A) has been found to play an essential role in such regulation. Here, we summarize newly discovered functions of m A...

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Vydáno v:Nature immunology Ročník 21; číslo 5; s. 501
Hlavní autoři: Shulman, Ziv, Stern-Ginossar, Noam
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.05.2020
Témata:
Adaptive Immunity - genetics
Adenosine - analogs & derivatives
Adenosine - genetics
Animals
Cell Differentiation
Humans
Immune System
Immunity, Innate - genetics
Immunomodulation
RNA - genetics
RNA Processing, Post-Transcriptional - immunology
ISSN:1529-2916
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Shrnutí:Protection from harmful pathogens depends on activation of the immune system, which relies on tight regulation of gene expression. Recently, the RNA modification N -methyladenosine (m A) has been found to play an essential role in such regulation. Here, we summarize newly discovered functions of m A in controlling various aspects of immunity, including immune recognition, activation of innate and adaptive immune responses, and cell fate decisions. We then discuss some of the current challenges in the field and describe future directions for uncovering the immunological functions of m A and its mechanisms of action.
ISSN:1529-2916
DOI:10.1038/s41590-020-0650-4