Tumor-educated T regs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche

Breast cancer is accompanied by systemic immunosuppression, which facilitates metastasis formation, but how this shapes organotropism of metastasis is poorly understood. Here, we investigate the impact of mammary tumorigenesis on regulatory T cells (T ) in distant organs and how this affects multi-o...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 38; no. 9; p. 110447
Main Authors:	Kos, Kevin, Aslam, Muhammad A, van de Ven, Rieneke, Wellenstein, Max D, Pieters, Wietske, van Weverwijk, Antoinette, Duits, Danique E M, van Pul, Kim, Hau, Cheei-Sing, Vrijland, Kim, Kaldenbach, Daphne, Raeven, Elisabeth A M, Quezada, Sergio A, Beyaert, Rudi, Jacobs, Heinz, de Gruijl, Tanja D, de Visser, Karin E
Format:	Journal Article
Language:	English
Published:	United States 01.03.2022
Subjects:	Animals Breast Neoplasms - pathology Carcinogenesis - pathology Female Humans Killer Cells, Natural - pathology Lymph Nodes Lymphatic Metastasis - pathology Mice NK cells lymph nodes T(regs) metastasis breast cancer immunosuppression organotropism
ISSN:	2211-1247
Online Access:	Get full text
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