Cross-linking of the DNA repair protein O 6 -alkylguanine DNA alkyltransferase to DNA in the presence of cisplatin

1,1,2,2-cis-diamminedichloroplatinum (II) (cisplatin) is a chemotherapeutic agent widely used in the clinic to treat various cancers. The antitumor activity of cisplatin is generally attributed to its ability to form intrastrand and interstrand DNA-DNA cross-links via sequential platination of two n...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	DNA repair Ročník 89; s. 102840
Hlavní autori:	Ming, Xun, Michaelson-Richie, Erin D, Groehler, 4th, Arnold S, Villalta, Peter W, Campbell, Colin, Tretyakova, Natalia Y
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands 01.05.2020
Predmet:	Antineoplastic Agents - pharmacology Chromatography, High Pressure Liquid Cisplatin - pharmacology Cross-Linking Reagents - pharmacology DNA - chemistry DNA Adducts Humans Models, Molecular O-Methylguanine-DNA Methyltransferase - chemistry Protein Conformation Recombinant Proteins Sequence Analysis, Protein Tandem Mass Spectrometry DNA-protein cross-links Mass spectrometry AGT Cisplatin
ISSN:	1568-7856
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!