The Influence of CG sites on dynamic DNA sequence mutagenesis in the genomic evolution of mammalian lifespan

Abstract Previous work showed that natural selection has acted to minimize the genomic frequencies of representative dynamic DNA sequences capable of forming G-quadruplex, Triplex, hairpin, and i-motif structures in long-lived mammals, thus diminishing the mutagenic potential of their genomes. This...

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Bibliographic Details

Published in:	Nucleic acids research Vol. 53; no. 15
Main Author:	Smith, Steven S
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 11.08.2025
Subjects:	Animals CpG Islands DNA Methylation Evolution, Molecular Genome Genome Integrity, Repair and Genomics Humans Longevity - genetics Mammals - genetics Mutagenesis Mutation Rate Nucleotide Motifs
ISSN:	0305-1048, 1362-4962, 1362-4962
Online Access:	Get full text
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