Intercalation‐Activated Layered MoO3 Nanobelts as Biodegradable Nanozymes for Tumor‐Specific Photo‐Enhanced Catalytic Therapy

The existence of natural van der Waals gaps in layered materials allows them to be easily intercalated with varying guest species, offering an appealing strategy to optimize their physicochemical properties and application performance. Herein, we report the activation of layered MoO3 nanobelts via a...

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Vydáno v:Angewandte Chemie (International ed.) Ročník 61; číslo 16; s. e202115939 - n/a
Hlavní autoři: Zhou, Zhan, Wang, Yanlong, Peng, Feng, Meng, Fanqi, Zha, Jiajia, Ma, Lu, Du, Yonghua, Peng, Na, Ma, Lufang, Zhang, Qinghua, Gu, Lin, Yin, Wenyan, Gu, Zhanjun, Tan, Chaoliang
Médium: Journal Article
Jazyk:angličtina
Vydáno: Weinheim Wiley Subscription Services, Inc 11.04.2022
Wiley
Vydání:International ed. in English
Témata:
Biodegradability
Biodegradation
Bovine serum albumin
Catalytic activity
Catalytic Therapy
Intercalation
Irradiation
Layered materials
Layered MoO3
MATERIALS SCIENCE
Mimicry
Molybdenum trioxide
Nanozymes
Physicochemical properties
Reactive oxygen species
Serum albumin
Tumor-Specific
Tumors
ISSN:1433-7851, 1521-3773, 1521-3773
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Shrnutí:The existence of natural van der Waals gaps in layered materials allows them to be easily intercalated with varying guest species, offering an appealing strategy to optimize their physicochemical properties and application performance. Herein, we report the activation of layered MoO3 nanobelts via aqueous intercalation as an efficient biodegradable nanozyme for tumor‐specific photo‐enhanced catalytic therapy. The long MoO3 nanobelts are grinded and then intercalated with Na+ and H2O to obtain the short Na+/H2O co‐intercalated MoO3−x (NH−MoO3−x) nanobelts. In contrast to the inert MoO3 nanobelts, the NH−MoO3−x nanobelts exhibit excellent enzyme‐mimicking catalytic activity for generation of reactive oxygen species, which can be further enhanced by the photothermal effect under a 1064 nm laser irradiation. Thus, after bovine serum albumin modification, the NH−MoO3−x nanobelts can efficiently kill cancer cells in vitro and eliminate tumors in vivo facilitating with 1064 nm laser irradiation. Aqueous intercalation is proposed here as a promising strategy to activate the enzyme‐mimicking catalytic activity of layered MoO3 nanobelts for the generation of reactive oxygen species including ⋅OH and ⋅O2− in a tumor microenvironment, making it an efficient biodegradable nanozyme for tumor‐specific photo‐enhanced catalytic therapy.
Bibliografie:These authors contributed equally to this work.
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National Basic Research Programs of China
SC0012704; 9610495; 9680297; 7020013; 22005259; 52122002
BNL-222732-2022-JAAM
National Natural Science Foundation of China (NSFC)
USDOE Office of Science (SC), Basic Energy Sciences (BES)
Beijing Natural Science Foundation
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.202115939