Intercalation‐Activated Layered MoO3 Nanobelts as Biodegradable Nanozymes for Tumor‐Specific Photo‐Enhanced Catalytic Therapy

The existence of natural van der Waals gaps in layered materials allows them to be easily intercalated with varying guest species, offering an appealing strategy to optimize their physicochemical properties and application performance. Herein, we report the activation of layered MoO3 nanobelts via a...

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Published in:Angewandte Chemie (International ed.) Vol. 61; no. 16; pp. e202115939 - n/a
Main Authors: Zhou, Zhan, Wang, Yanlong, Peng, Feng, Meng, Fanqi, Zha, Jiajia, Ma, Lu, Du, Yonghua, Peng, Na, Ma, Lufang, Zhang, Qinghua, Gu, Lin, Yin, Wenyan, Gu, Zhanjun, Tan, Chaoliang
Format: Journal Article
Language:English
Published: Weinheim Wiley Subscription Services, Inc 11.04.2022
Wiley
Edition:International ed. in English
Subjects:
Biodegradability
Biodegradation
Bovine serum albumin
Catalytic activity
Catalytic Therapy
Intercalation
Irradiation
Layered materials
Layered MoO3
MATERIALS SCIENCE
Mimicry
Molybdenum trioxide
Nanozymes
Physicochemical properties
Reactive oxygen species
Serum albumin
Tumor-Specific
Tumors
ISSN:1433-7851, 1521-3773, 1521-3773
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Abstract The existence of natural van der Waals gaps in layered materials allows them to be easily intercalated with varying guest species, offering an appealing strategy to optimize their physicochemical properties and application performance. Herein, we report the activation of layered MoO3 nanobelts via aqueous intercalation as an efficient biodegradable nanozyme for tumor‐specific photo‐enhanced catalytic therapy. The long MoO3 nanobelts are grinded and then intercalated with Na+ and H2O to obtain the short Na+/H2O co‐intercalated MoO3−x (NH−MoO3−x) nanobelts. In contrast to the inert MoO3 nanobelts, the NH−MoO3−x nanobelts exhibit excellent enzyme‐mimicking catalytic activity for generation of reactive oxygen species, which can be further enhanced by the photothermal effect under a 1064 nm laser irradiation. Thus, after bovine serum albumin modification, the NH−MoO3−x nanobelts can efficiently kill cancer cells in vitro and eliminate tumors in vivo facilitating with 1064 nm laser irradiation. Aqueous intercalation is proposed here as a promising strategy to activate the enzyme‐mimicking catalytic activity of layered MoO3 nanobelts for the generation of reactive oxygen species including ⋅OH and ⋅O2− in a tumor microenvironment, making it an efficient biodegradable nanozyme for tumor‐specific photo‐enhanced catalytic therapy.
AbstractList The existence of natural van der Waals gaps in layered materials allows them to be easily intercalated with varying guest species, offering an appealing strategy to optimize their physicochemical properties and application performance. Herein, we report the activation of layered MoO3 nanobelts via aqueous intercalation as an efficient biodegradable nanozyme for tumor‐specific photo‐enhanced catalytic therapy. The long MoO3 nanobelts are grinded and then intercalated with Na+ and H2O to obtain the short Na+/H2O co‐intercalated MoO3−x (NH−MoO3−x) nanobelts. In contrast to the inert MoO3 nanobelts, the NH−MoO3−x nanobelts exhibit excellent enzyme‐mimicking catalytic activity for generation of reactive oxygen species, which can be further enhanced by the photothermal effect under a 1064 nm laser irradiation. Thus, after bovine serum albumin modification, the NH−MoO3−x nanobelts can efficiently kill cancer cells in vitro and eliminate tumors in vivo facilitating with 1064 nm laser irradiation. Aqueous intercalation is proposed here as a promising strategy to activate the enzyme‐mimicking catalytic activity of layered MoO3 nanobelts for the generation of reactive oxygen species including ⋅OH and ⋅O2− in a tumor microenvironment, making it an efficient biodegradable nanozyme for tumor‐specific photo‐enhanced catalytic therapy.
The existence of natural van der Waals gaps in layered materials allows them to be easily intercalated with varying guest species, offering an appealing strategy to optimize their physicochemical properties and application performance. Herein, we report the activation of layered MoO3 nanobelts via aqueous intercalation as an efficient biodegradable nanozyme for tumor-specific photo-enhanced catalytic therapy. In this work, the long MoO3 nanobelts are grinded and then intercalated with Na+ and H2O to obtain the short Na+/H2O co-intercalated MoO3–x (NH–MoO3–x) nanobelts. In contrast to the inert MoO3 nanobelts, the NH–MoO3–x nanobelts exhibit excellent enzyme-mimicking catalytic activity for generation of reactive oxygen species, which can be further enhanced by the photothermal effect under a 1064 nm laser irradiation. Thus, after bovine serum albumin modification, the NH–MoO3–x nanobelts can efficiently kill cancer cells in vitro and eliminate tumors in vivo facilitating with 1064 nm laser irradiation.
The existence of natural van der Waals gaps in layered materials allows them to be easily intercalated with varying guest species, offering an appealing strategy to optimize their physicochemical properties and application performance. Herein, we report the activation of layered MoO3 nanobelts via aqueous intercalation as an efficient biodegradable nanozyme for tumor-specific photo-enhanced catalytic therapy. The long MoO3 nanobelts are grinded and then intercalated with Na+ and H2 O to obtain the short Na+ /H2 O co-intercalated MoO3-x (NH-MoO3-x ) nanobelts. In contrast to the inert MoO3 nanobelts, the NH-MoO3-x nanobelts exhibit excellent enzyme-mimicking catalytic activity for generation of reactive oxygen species, which can be further enhanced by the photothermal effect under a 1064 nm laser irradiation. Thus, after bovine serum albumin modification, the NH-MoO3-x nanobelts can efficiently kill cancer cells in vitro and eliminate tumors in vivo facilitating with 1064 nm laser irradiation.The existence of natural van der Waals gaps in layered materials allows them to be easily intercalated with varying guest species, offering an appealing strategy to optimize their physicochemical properties and application performance. Herein, we report the activation of layered MoO3 nanobelts via aqueous intercalation as an efficient biodegradable nanozyme for tumor-specific photo-enhanced catalytic therapy. The long MoO3 nanobelts are grinded and then intercalated with Na+ and H2 O to obtain the short Na+ /H2 O co-intercalated MoO3-x (NH-MoO3-x ) nanobelts. In contrast to the inert MoO3 nanobelts, the NH-MoO3-x nanobelts exhibit excellent enzyme-mimicking catalytic activity for generation of reactive oxygen species, which can be further enhanced by the photothermal effect under a 1064 nm laser irradiation. Thus, after bovine serum albumin modification, the NH-MoO3-x nanobelts can efficiently kill cancer cells in vitro and eliminate tumors in vivo facilitating with 1064 nm laser irradiation.
The existence of natural van der Waals gaps in layered materials allows them to be easily intercalated with varying guest species, offering an appealing strategy to optimize their physicochemical properties and application performance. Herein, we report the activation of layered MoO3 nanobelts via aqueous intercalation as an efficient biodegradable nanozyme for tumor‐specific photo‐enhanced catalytic therapy. The long MoO3 nanobelts are grinded and then intercalated with Na+ and H2O to obtain the short Na+/H2O co‐intercalated MoO3−x (NH−MoO3−x) nanobelts. In contrast to the inert MoO3 nanobelts, the NH−MoO3−x nanobelts exhibit excellent enzyme‐mimicking catalytic activity for generation of reactive oxygen species, which can be further enhanced by the photothermal effect under a 1064 nm laser irradiation. Thus, after bovine serum albumin modification, the NH−MoO3−x nanobelts can efficiently kill cancer cells in vitro and eliminate tumors in vivo facilitating with 1064 nm laser irradiation.
Author Ma, Lu
Zhang, Qinghua
Yin, Wenyan
Zha, Jiajia
Wang, Yanlong
Du, Yonghua
Gu, Lin
Ma, Lufang
Peng, Feng
Gu, Zhanjun
Peng, Na
Zhou, Zhan
Meng, Fanqi
Tan, Chaoliang
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  email: chaoltan@cityu.edu.hk
  organization: City University of Hong Kong
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Snippet The existence of natural van der Waals gaps in layered materials allows them to be easily intercalated with varying guest species, offering an appealing...
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SubjectTerms Biodegradability
Biodegradation
Bovine serum albumin
Catalytic activity
Catalytic Therapy
Intercalation
Irradiation
Layered materials
Layered MoO3
MATERIALS SCIENCE
Mimicry
Molybdenum trioxide
Nanozymes
Physicochemical properties
Reactive oxygen species
Serum albumin
Tumor-Specific
Tumors
Title Intercalation‐Activated Layered MoO3 Nanobelts as Biodegradable Nanozymes for Tumor‐Specific Photo‐Enhanced Catalytic Therapy
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fanie.202115939
https://www.proquest.com/docview/2646640651
https://www.proquest.com/docview/2622963273
https://www.osti.gov/servlets/purl/1844569
Volume 61
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