Lenalidomide after Stem-Cell Transplantation for Multiple Myeloma

In patients who had undergone stem-cell transplantation, lenalidomide maintenance therapy improved progression-free and overall survival, though at the expense of some increased hematologic toxicity and second malignant tumors. A goal of therapy for multiple myeloma, to induce complete remission and...

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Vydané v:The New England journal of medicine Ročník 366; číslo 19; s. 1770 - 1781
Hlavní autori: McCarthy, Philip L, Owzar, Kouros, Hofmeister, Craig C, Hurd, David D, Hassoun, Hani, Richardson, Paul G, Giralt, Sergio, Stadtmauer, Edward A, Weisdorf, Daniel J, Vij, Ravi, Moreb, Jan S, Callander, Natalie Scott, Van Besien, Koen, Gentile, Teresa, Isola, Luis, Maziarz, Richard T, Gabriel, Don A, Bashey, Asad, Landau, Heather, Martin, Thomas, Qazilbash, Muzaffar H, Levitan, Denise, McClune, Brian, Schlossman, Robert, Hars, Vera, Postiglione, John, Jiang, Chen, Bennett, Elizabeth, Barry, Susan, Bressler, Linda, Kelly, Michael, Seiler, Michele, Rosenbaum, Cara, Hari, Parameswaran, Pasquini, Marcelo C, Horowitz, Mary M, Shea, Thomas C, Devine, Steven M, Anderson, Kenneth C, Linker, Charles
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Massachusetts Medical Society 10.05.2012
Predmet:
Adult
Aged
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
Autografts
Cancer
Cancer therapies
Clinical trials
Disease-Free Survival
Double-Blind Method
Female
Follow-Up Studies
Humans
Immunotherapy
Lenalidomide
Maintenance Chemotherapy
Male
Middle Aged
Multiple myeloma
Multiple Myeloma - drug therapy
Multiple Myeloma - mortality
Multiple Myeloma - therapy
Neoplasms, Second Primary - epidemiology
Stem Cell Transplantation
Targeted cancer therapy
Thalidomide - adverse effects
Thalidomide - analogs & derivatives
Thalidomide - therapeutic use
Toxicity
Transplants & implants
ISSN:0028-4793, 1533-4406, 1533-4406
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Shrnutí:In patients who had undergone stem-cell transplantation, lenalidomide maintenance therapy improved progression-free and overall survival, though at the expense of some increased hematologic toxicity and second malignant tumors. A goal of therapy for multiple myeloma, to induce complete remission and prolong survival, is usually accomplished with combination therapy. 1 , 2 Autologous hematopoietic stem-cell transplantation is often used after induction chemotherapy to improve the response or to consolidate complete remission. 1 , 2 However, since most patients with multiple myeloma have disease recurrence or progression after transplantation, maintenance therapies have been used to prolong complete remission and prevent relapse or progressive disease. Low-dose melphalan, interferon alfa, and glucocorticoids have been used for maintenance after primary therapy, but their long-term use is limited by toxicity and modest efficacy. 3 – 6 Five studies involving patients who . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1114083