An Alarmingly High Proportion of HIV-1 Isolates Carrying Mutations Corresponding to Resistance to Antiretroviral Drugs among HIV-Positive High-Risk Groups in Central Vietnam: a Substudy of the National Sentinel Survey

We studied the prevalence of HIV drug resistance among high-risk groups such as injecting drug users (IDUs), female sex workers (FSWs), and men having sex with men (MSM) in central Vietnam. We used HIV-positive blood samples from 2012-2013 sentinel surveillance surveys. Study subjects were screened...

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Veröffentlicht in:Japanese journal of infectious diseases Jg. 70; H. 6; S. 621
Hauptverfasser: Do, Hung Thai, Nguyen, Dong Thanh, Nguyen, Lan Anh Thi, Do, Duong Huy, Le, Huy Xuan, Trinh, Xuan Mai Thi, Ton, Hong Vy Nu, Sawada, Ikumi, Kitamura, Noriko, Le, Minh Nhat, Yoshihara, Keisuke, Phan, Thu Huong Thi, Bui, Chien Trong, Ariyoshi, Koya, Yoshida, Lay Myint
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Japan 2017
Schlagworte:
Adolescent
Adult
Anti-HIV Agents - pharmacology
Drug Resistance, Viral
Female
HIV Infections - epidemiology
HIV Infections - virology
HIV Seropositivity
HIV-1 - classification
HIV-1 - drug effects
HIV-1 - genetics
HIV-1 - isolation & purification
Humans
Male
Middle Aged
Mutation
Phylogeny
Population Surveillance
Sentinel Surveillance
Sequence Analysis, DNA
Sex Workers
Substance Abuse, Intravenous
Vietnam - epidemiology
Viral Load
Young Adult
antiretroviral drug resistance
risk behavior
human immunodeficiency virus (HIV)
high-risk group
ISSN:1884-2836, 1884-2836
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Zusammenfassung:We studied the prevalence of HIV drug resistance among high-risk groups such as injecting drug users (IDUs), female sex workers (FSWs), and men having sex with men (MSM) in central Vietnam. We used HIV-positive blood samples from 2012-2013 sentinel surveillance surveys. Study subjects were screened for HIV infection by standardized screening assays, and the HIV-positive samples were further tested for HIV viral load and drug-resistance mutations (DRMs) by in-house assays. DRMs were identified using the Stanford University online sequence analysis tool. Their risk behaviors were also investigated. During the study period, 6,016 (high-risk) subjects were screened, and 97 tested positive for HIV infection (IDUs: n = 63, 3.0%; FSWs: n = 24, 0.9%; and MSM: n = 10, 1.0%). Ninety-two of the 97 samples (45 from 2012 and 47 from 2013) were available for further testing. HIV RNA was detected in 56 (60.9%) of the 92 samples, and drug resistance genotyping was successfully performed on 40 (71.4%) samples. All these isolates were subtype CRF01_AE, except for 1 (2.5%) IDU whose HIV belongs to subtype B. Thirteen individuals (32.5%) were carrying HIV with at least 1 DRM: 9 IDUs, 1 FSW, and 3 MSM. Thus, HIV seroprevalence among high-risk individuals in central Vietnam is low, but a high proportion of drug resistant HIV-1 isolates is observed in the high-risk group.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1884-2836
1884-2836
DOI:10.7883/yoken.JJID.2016.512