NSUN2‐Mediated m5C Methylation and METTL3/METTL14‐Mediated m6A Methylation Cooperatively Enhance p21 Translation

ABSTRACT N6‐methyladenosine (m6A) and m5C methylation are two major types of RNA methylation, but the impact of joint modifications on the same mRNA is unknown. Here, we show that in p21 3′UTR, NSUN2 catalyzes m5C modification and METTL3/METTL14 catalyzes m6A modification. Interestingly, methylation...

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Bibliographic Details
Published in:	Journal of cellular biochemistry Vol. 118; no. 9; pp. 2587 - 2598
Main Authors:	Li, Qiu, Li, Xiu, Tang, Hao, Jiang, Bin, Dou, Yali, Gorospe, Myriam, Wang, Wengong
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.09.2017
Subjects:	3' Untranslated Regions Adenosine - analogs & derivatives Adenosine - genetics Adenosine - metabolism Biochemistry Cellular Senescence - genetics Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis Cyclin-Dependent Kinase Inhibitor p21 - genetics Gene expression Gene Expression Regulation GTP-binding protein HeLa Cells Humans Methylation Methyltransferases - genetics Methyltransferases - metabolism METTL14 METTL3 N6-methyladenosine NSUN2 Oxidative stress Oxidative Stress - genetics p21 mRNA METHYLATION Protein Biosynthesis Ribonucleic acid RNA RNA modification Senescence Translation TRANSLATIONAL REGULATION METTL14 TRANSLATIONAL REGULATION NSUN2 p21 mRNA METHYLATION METTL3
ISSN:	0730-2312, 1097-4644, 1097-4644
Online Access:	Get full text
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