Allergic contact dermatitis caused by isobornyl acrylate in Freestyle® Libre, a newly introduced glucose sensor

SUMMARY Background Glucose sensors, such as FreeStyle® Libre, are innovative medical devices developed for diabetes patients as a replacement for classic glucose meters, ensuring continuous glucose monitoring without the disadvantage of regular skin finger pricks. Objectives To report several cases...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Contact dermatitis Ročník 77; číslo 6; s. 367 - 373
Hlavní autoři: Herman, Anne, Aerts, Olivier, Baeck, Marie, Bruze, Magnus, De Block, Christophe, Goossens, An, Hamnerius, Nils, Huygens, Sara, Maiter, Dominique, Tennstedt, Dominique, Vandeleene, Bernard, Mowitz, Martin
Médium: Journal Article
Jazyk:angličtina
Vydáno: Oxford, UK Blackwell Publishing Ltd 01.12.2017
Wiley Subscription Services, Inc
Témata:
acrylates
Acrylates - administration & dosage
Acrylates - adverse effects
adhesive
Adhesives
Administration, Cutaneous
Allergens
allergic contact dermatitis
Allergies
Blood Glucose - analysis
Blood Glucose Self-Monitoring - adverse effects
Blood Glucose Self-Monitoring - instrumentation
Bornanes - administration & dosage
Bornanes - adverse effects
CAS no. 5888‐33‐5
Clinical Medicine
Contact dermatitis
Cross-reactivity
Dermatitis
Dermatitis, Allergic Contact - etiology
Dermatologi och venereologi
Dermatology and Venereal Diseases
Diabetes mellitus
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 2 - blood
Eczema
FreeStyle® Libre
Gas chromatography
Gas Chromatography-Mass Spectrometry
Glucose
Glucose monitoring
glucose sensor
Humans
isobornyl acrylate
Klinisk medicin
mass spectrometry
Mass spectroscopy
Medical and Health Sciences
medical device
Medical equipment
Medical innovations
Medicin och hälsovetenskap
Sensors
sesquiterpene lactone mix
Skin
CAS no. 5888-33-5
glucose sensor
allergic contact dermatitis
isobornyl acrylate
FreeStyle® Libre
acrylates
mass spectrometry
diabetes mellitus
adhesive
gas chromatography
medical device
sesquiterpene lactone mix
ISSN:0105-1873, 1600-0536, 1600-0536
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:SUMMARY Background Glucose sensors, such as FreeStyle® Libre, are innovative medical devices developed for diabetes patients as a replacement for classic glucose meters, ensuring continuous glucose monitoring without the disadvantage of regular skin finger pricks. Objectives To report several cases of allergic contact dermatitis caused by FreeStyle® Libre, and to report on isobornyl acrylate as a culprit allergen. Patients and Methods Fifteen patients presented with allergic contact dermatitis caused by FreeStyle® Libre. All but 1 were patch tested with a baseline series, and with pieces and/or ultrasonic bath extracts of (the adhesive part of) the glucose sensor. Isobornyl acrylate was patch tested, in various concentrations and vehicles, in 13 patients. Gas chromatography–mass spectrometry (GC‐MS) of the sensors was performed. Results All patients reacted to the adhesive part of the sensor, and 12 patients were shown to be sensitized to isobornyl acrylate. Simultaneous reactions to other allergens were rarely observed. GC‐MS showed the presence of isobornyl acrylate in the sensors. Conclusions Cases of allergic contact dermatitis caused by FreeStyle® Libre are increasingly being observed, and isobornyl acrylate is a relevant culprit allergen. Cross‐reactivity to other acrylates was infrequently observed, but other, hitherto unidentified, contact allergens may still be present in the device.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0105-1873
1600-0536
1600-0536
DOI:10.1111/cod.12866