LuCaP Prostate Cancer Patient‐Derived Xenografts Reflect the Molecular Heterogeneity of Advanced Disease an­­d Serve as Models for Evaluating Cancer Therapeutics

BACKGROUND Metastatic prostate cancer is a common and lethal disease for which there are no therapies that produce cures or long‐term durable remissions. Clinically relevant preclinical models are needed to increase our understanding of biology of this malignancy and to evaluate new agents that migh...

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Bibliographic Details
Published in:The Prostate Vol. 77; no. 6; pp. 654 - 671
Main Authors: Nguyen, Holly M., Vessella, Robert L., Morrissey, Colm, Brown, Lisha G., Coleman, Ilsa M., Higano, Celestia S., Mostaghel, Elahe A., Zhang, Xiaotun, True, Lawrence D., Lam, Hung‐Ming, Roudier, Martine, Lange, Paul H., Nelson, Peter S., Corey, Eva
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01.05.2017
John Wiley and Sons Inc
Subjects:
Animals
bone response
Genetic Heterogeneity
Heterografts - pathology
Humans
Male
Mice
Mice, Nude
Mice, SCID
Original
patient‐derived xenografts
prostate cancer
Prostatic Neoplasms, Castration-Resistant - genetics
Prostatic Neoplasms, Castration-Resistant - pathology
response to castration
Tumor Burden - genetics
Xenograft Model Antitumor Assays - methods
prostate cancer
response to castration
bone response
patient-derived xenografts
ISSN:0270-4137, 1097-0045
Online Access:Get full text
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