PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey

Colony-stimulating factor 1 receptor (CSF1R) is a specific biomarker for microglia. In this study, we developed a novel PET radioligand for CSF1R, 11C-GW2580, and compared it to a reported CSF1R tracer, 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey. Dynamic 11C...

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Bibliographic Details
Published in:	Journal of cerebral blood flow and metabolism Vol. 41; no. 9; p. 2410
Main Authors:	Zhou, Xiaoyun, Ji, Bin, Seki, Chie, Nagai, Yuji, Minamimoto, Takafumi, Fujinaga, Masayuki, Zhang, Ming-Rong, Saito, Takashi, Saido, Takaomi C, Suhara, Tetsuya, Kimura, Yasuyuki, Higuchi, Makoto
Format:	Journal Article
Language:	English
Published:	01.09.2021
ISSN:	1559-7016, 1559-7016
Online Access:	Get more information
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