STUB1 suppresseses tumorigenesis and chemoresistance through antagonizing YAP1 signaling

Yes‐associated protein (YAP) is a component of the canonical Hippo signaling pathway that is known to play essential roles in modulating organ size, development, and tumorigenesis. Activation or upregulation of YAP1, which contributes to cancer cell survival and chemoresistance, has been verified in...

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Veröffentlicht in:	Cancer science Jg. 110; H. 10; S. 3145 - 3156
Hauptverfasser:	Tang, Dong‐E, Dai, Yong, Lin, Lie‐Wen, Xu, Yong, Liu, Dong‐Zhou, Hong, Xiao‐Ping, Jiang, Hao‐Wu, Xu, Song‐Hui
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England John Wiley & Sons, Inc 01.10.2019 John Wiley and Sons Inc
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - metabolism Animals Carcinogenesis Cell growth Cell Line, Tumor Cell Proliferation Cell survival Chemoresistance Drug Resistance, Neoplasm Female Gastric cancer Gene Expression Regulation, Neoplastic HEK293 Cells Humans Kinases Lysine - metabolism Mass spectrometry Medical prognosis Mice Mutation Neoplasm Transplantation Original Peptides Phosphoproteins - chemistry Phosphoproteins - metabolism Plasmids Protein Stability Proteins Proteolysis Scientific imaging Signal Transduction Statistical analysis Stomach Neoplasms - drug therapy Stomach Neoplasms - metabolism Stomach Neoplasms - pathology STUB1 Therapeutic applications Transcription Factors Tumor cell lines Tumorigenesis Tumors Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism Ubiquitination YAP-Signaling Proteins YAP1 Yes-associated protein China YAP1 chemoresistance STUB1 gastric cancer ubiquitination
ISSN:	1347-9032, 1349-7006, 1349-7006
Online-Zugang:	Volltext
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