Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP)

Angiotensin IV (Ang IV) exerts profound effects on memory and learning, a phenomenon ascribed to its binding to a specific AT4 receptor. However the AT4 receptor has recently been identified as the insulin‐regulated aminopeptidase (IRAP). In this study, we demonstrate that AT4 receptor ligands, incl...

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Bibliographic Details
Published in:	Journal of neurochemistry Vol. 86; no. 2; pp. 344 - 350
Main Authors:	Lew, Rebecca A., Mustafa, Tomris, Ye, Siying, McDowall, Sharon G., Chai, Siew Yeen, Albiston, Anthony L.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Ltd 01.07.2003 Blackwell
Subjects:	Aminopeptidases - antagonists & inhibitors Aminopeptidases - chemistry Aminopeptidases - metabolism Ang IV Angiotensin II - analogs & derivatives Angiotensin II - pharmacology Angiotensin Receptor Antagonists AT4 receptor Binding, Competitive - drug effects Biological and medical sciences Cell Line Cell receptors Cell structures and functions Cystinyl Aminopeptidase Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology enzyme kinetics Fundamental and applied biological sciences. Psychology Hemoglobins - pharmacology hemorphin Humans Kidney - cytology Kidney - metabolism Leucine - analogs & derivatives Leucine - metabolism Ligands Miscellaneous Molecular and cellular biology Oligopeptides - pharmacology Peptide Fragments - pharmacology Peptides - chemistry Peptides - metabolism Receptors, Angiotensin - chemistry Receptors, Angiotensin - metabolism Recombinant Proteins Substrate Specificity - physiology Ligand binding Enzyme Aminopeptidases Binding site Angiotensin receptor Angiotensin IV Gene expression enzyme kinetics Peptidases Renin angiotensin system Cell line Proteolysis AT4 receptor Angiotensin Hydrolases AT4 angiotensin receptor Kinetics Ang IV hemorphin
ISSN:	0022-3042, 1471-4159
Online Access:	Get full text
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