m6A RNA methylation: from mechanisms to therapeutic potential

RNA carries a diverse array of chemical modifications that play important roles in the regulation of gene expression. N 6 ‐methyladenosine (m 6 A), installed onto mRNA by the METTL3/METTL14 methyltransferase complex, is the most prevalent mRNA modification. m 6 A methylation regulates gene expressio...

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Vydané v:	The EMBO journal Ročník 40; číslo 3
Hlavní autori:	He, P Cody, He, Chuan
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 01.02.2021 Springer Nature B.V John Wiley and Sons Inc
Predmet:	Decay DNA methylation EMBO36 epitranscriptome Gene expression Gene regulation m6A methylation Methylation Methyltransferase mRNA mRNA processing mRNA turnover N6-methyladenosine Nuclear transport Review Reviews Ribonucleic acid RNA RNA modification RNA modifications Substrates Transcription Translation epitranscriptome mRNA m A methylation gene expression RNA modifications
ISSN:	0261-4189, 1460-2075
On-line prístup:	Získať plný text
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