A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study

To construct a polygenic risk score (PRS) for coronary artery disease (CAD) and comprehensively evaluate its potential in clinical utility for primary prevention in Chinese populations. Using meta-analytic approach and large genome-wide association results for CAD and CAD-related traits in East Asia...

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Vydáno v:	European heart journal Ročník 43; číslo 18; s. 1702
Hlavní autoři:	Lu, Xiangfeng, Liu, Zhongying, Cui, Qingmei, Liu, Fangchao, Li, Jianxin, Niu, Xiaoge, Shen, Chong, Hu, Dongsheng, Huang, Keyong, Chen, Jichun, Xing, Xiaolong, Zhao, Yingxin, Lu, Fanghong, Liu, Xiaoqing, Cao, Jie, Chen, Shufeng, Ma, Hongxia, Yu, Ling, Wu, Xianping, Wu, Xigui, Li, Ying, Zhang, Huan, Mo, Xingbo, Zhao, Liancheng, Huang, Jianfeng, Wang, Laiyuan, Wen, Wanqing, Shu, Xiao-Ou, Takeuchi, Fumihiko, Koh, Woon-Puay, Tai, E Shyong, Cheng, Ching-Yu, Wong, Tien Yin, Chang, Xuling, Chan, Mark Yan-Yee, Gao, Wei, Zheng, Hong, Chen, Kexin, Chen, Jing, He, Jiang, Tang, Clara Sze-Man, Lam, Karen Siu Ling, Tse, Hung-Fat, Cheung, Chloe Yu Yan, Takahashi, Atsushi, Kubo, Michiaki, Kato, Norihiro, Terao, Chikashi, Kamatani, Yoichiro, Sham, Pak Chung, Heng, Chew-Kiat, Hu, Zhibin, Chen, Y Eugene, Wu, Tangchun, Shen, Hongbing, Willer, Cristen J, Gu, Dongfeng
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 07.05.2022
Témata:	Asian People China - epidemiology Cohort Studies Coronary Artery Disease - epidemiology Coronary Artery Disease - genetics Genetic Predisposition to Disease - genetics Genome-Wide Association Study Humans Multifactorial Inheritance - genetics Prospective Studies Risk Assessment - methods Risk Factors China Polygenic risk score Clinical risk score Coronary artery disease
ISSN:	1522-9645, 1522-9645
On-line přístup:	Zjistit podrobnosti o přístupu
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