Dysregulated atrial gene expression of osteoprotegerin/receptor activator of nuclear factor-κB (RANK)/RANK ligand axis in the development and progression of atrial fibrillation

Atrial structural remodeling is increasingly emphasized in initiation and perpetuation of atrial fibrillation (AF). Osteoprotegerin (OPG)/receptor activator of nuclear factor-κB (RANK)/RANK ligand (RANKL) axis, a key regulatory system in bone homeostasis, was recently linked to some cardiovascular d...

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Vydáno v:	Circulation journal : official journal of the Japanese Circulation Society Ročník 75; číslo 12; s. 2781
Hlavní autoři:	Cao, Hailong, Wang, Jian, Xi, Lei, Røe, Oluf Dimitri, Chen, Yijiang, Wang, Dongjin
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Japan 2011
Témata:	Adult Atrial Fibrillation - genetics Atrial Fibrillation - metabolism Atrial Fibrillation - therapy Disease Progression Female Gene Expression Regulation Heart Atria - metabolism Humans Interleukin-6 - biosynthesis Interleukin-6 - genetics Male Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - genetics Middle Aged Osteoprotegerin - biosynthesis Osteoprotegerin - genetics RANK Ligand - biosynthesis RANK Ligand - genetics Receptor Activator of Nuclear Factor-kappa B - biosynthesis Receptor Activator of Nuclear Factor-kappa B - genetics Tissue Inhibitor of Metalloproteinase-1 - biosynthesis Tissue Inhibitor of Metalloproteinase-1 - genetics Tissue Inhibitor of Metalloproteinase-2 - biosynthesis Tissue Inhibitor of Metalloproteinase-2 - genetics Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics
ISSN:	1347-4820, 1347-4820
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