Binding characteristics and sensitivity to endogenous dopamine of [11C]‐(+)‐PHNO, a new agonist radiotracer for imaging the high‐affinity state of D2 receptors in vivo using positron emission tomography

[11C]‐(+)‐PHNO (4‐propyl‐9‐hydroxynaphthoxazine) is a new agonist radioligand that provides a unique opportunity to measure the high‐affinity states of the D2 receptors (D2‐high) using positron emission tomography (PET). Here we report on the distribution, displaceablity, specificity and modeling of...

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Bibliographic Details
Published in:	Journal of neurochemistry Vol. 97; no. 4; pp. 1089 - 1103
Main Authors:	Ginovart, Nathalie, Galineau, Laurent, Willeit, Matthaeus, Mizrahi, Romina, Bloomfield, Peter M., Seeman, Philip, Houle, Sylvain, Kapur, Shitij, Wilson, Alan A.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01.05.2006 Blackwell
Subjects:	Amphetamine - pharmacology Animals Binding sites Binding Sites - physiology Binding, Competitive - drug effects Binding, Competitive - physiology Biological and medical sciences Brain - diagnostic imaging Brain - metabolism Brain Chemistry - drug effects Brain Chemistry - physiology Carbon Radioisotopes - metabolism Cats Cell receptors Cell structures and functions Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Comparative analysis Corpus Striatum - drug effects Corpus Striatum - metabolism D2 receptors dopamine Dopamine - metabolism Dopamine Agonists - metabolism Dopamine Agonists - pharmacokinetics Dopamine Antagonists - metabolism Dopamine Antagonists - pharmacokinetics Dose-Response Relationship, Drug d‐amphetamine Fundamental and applied biological sciences. Psychology Male Molecular and cellular biology Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) naphthoxazine derivatives Neurology Neurotransmitters Oxazines - metabolism Oxazines - pharmacokinetics Positron-Emission Tomography - methods Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism raclopride Raclopride - metabolism Receptors, Dopamine D2 - drug effects Receptors, Dopamine D2 - metabolism Synaptic Transmission - drug effects Synaptic Transmission - physiology Tomography Vertebrates: nervous system and sense organs Central nervous system d-amphetamine Modeling Encephalon raclopride Specificity Endogenous D2 receptors Antagonist Fissipedia Carnivora Dopamine Basal ganglion Corpus striatum Catecholamine Uptake Vertebrata Sensitivity Mammalia D2 Dopamine receptor naphthoxazine derivatives Cat Neurotransmitter Positron Emission tomography
ISSN:	0022-3042, 1471-4159
Online Access:	Get full text
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