ArtTwin: A Novel Concept of Developing Digital Twin of Human Arterial System

Pulse waveforms contain rich hemodynamic information, essential for real-time patient-specific diagnosis. While most research focuses on predicting central waveforms from peripheral waveforms and extracting hemodynamic data, we explore the potential of analyzing real-time pulse waveforms across the...

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Vydáno v:Proceedings of the ... IEEE International Conference on Acoustics, Speech and Signal Processing (1998) s. 1 - 5
Hlavní autoři: Hemanthika, Akasapu, Chandran, Dinu S, Kumar, Sandeep, Roy, Sitikantha
Médium: Konferenční příspěvek
Jazyk:angličtina
Vydáno: IEEE 06.04.2025
Témata:
Accuracy
Arteries
autoen-coder
compressed sensing
Computational fluid dynamics
digital twin
Digital twins
graph neural networks
Hemodynamics
human arterial system
pulse waveforms
Real-time systems
sparse reconstruction
Surgery
Synthetic data
Testing
Training
ISSN:2379-190X
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Shrnutí:Pulse waveforms contain rich hemodynamic information, essential for real-time patient-specific diagnosis. While most research focuses on predicting central waveforms from peripheral waveforms and extracting hemodynamic data, we explore the potential of analyzing real-time pulse waveforms across the entire arterial system. This approach enables the creation of a digital twin of the human arterial system or ArtTwin. ArtTwin should use pulse waveforms measured in real-time at sparse locations to predict corresponding waveforms throughout the arterial system for practical application. This work conceptualizes ArtTwin as a sparse reconstruction problem, solvable through a graph-based autoencoder model. We enhance reconstruction accuracy by incorporating Singular Value Decomposition (SVD) modes. The efficiency of ArtTwin is demonstrated as a proof of concept using virtual patient data of blood pressure (P) and velocity (U) pulse waveforms generated from a traditional computational fluid dynamics (CFD) based one-dimensional blood flow solver. Our results show that ArtTwin can accurately predict pressure and velocity waveforms throughout the arterial system using data from just one peripheral artery location. These findings validate the concept of ArtTwin and support its potential for real-time applications. The code for implementing ArtTwin is available at: https://github.com/AHemanthika/ArtTwin
ISSN:2379-190X
DOI:10.1109/ICASSP49660.2025.10888901