MPC-based Anesthesiologists Imitating Control of Propofol and Remifentanil during Anesthesia Maintenance

This paper suggests a new formulation of a Model Predictive Control (MPC) strategy, allowing to design propofol and remifentanil infusion profiles in order to control the Bispectal Index (BIS). This new formulation, based on a range cost, allows to reduce the sensitivity of the control profiles with...

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Bibliographic Details
Published in:International Conference on System Theory, Control and Computing pp. 588 - 594
Main Authors: Raymond, Maxim, Moussa, Kaouther, Fiacchini, Mirko, Lauber, Jimmy
Format: Conference Proceeding
Language:English
Published: IEEE 09.10.2025
Subjects:
Anesthesia
anesthesia dynamics
anesthesiologist mimicking
Codes
Costs
Event detection
Maintenance
Model Predictive Control
Noise
Predictive control
Statistical analysis
Surgery
ISSN:2473-5698
Online Access:Get full text
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Summary:This paper suggests a new formulation of a Model Predictive Control (MPC) strategy, allowing to design propofol and remifentanil infusion profiles in order to control the Bispectal Index (BIS). This new formulation, based on a range cost, allows to reduce the sensitivity of the control profiles with respect to the BIS measurement noise. Furthermore, it allows to better represent the anesthesiologists behavior in practice, who usually do not over-react to small changes in the measured health indicators. The paper assesses numerically this formulation, by comparing its performance, in an uncertain setting, to standard set-point tracking based MPC strategies.
ISSN:2473-5698
DOI:10.1109/ICSTCC66753.2025.11240385