Ebola virus entry requires the host-programmed recognition of an intracellular receptor

Ebola and Marburg filoviruses cause deadly outbreaks of haemorrhagic fever. Despite considerable efforts, no essential cellular receptors for filovirus entry have been identified. We showed previously that Niemann‐Pick C1 (NPC1), a lysosomal cholesterol transporter, is required for filovirus entry....

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Vydáno v:	The EMBO journal Ročník 31; číslo 8; s. 1947 - 1960
Hlavní autoři:	Miller, Emily Happy, Obernosterer, Gregor, Raaben, Matthijs, Herbert, Andrew S, Deffieu, Maika S, Krishnan, Anuja, Ndungo, Esther, Sandesara, Rohini G, Carette, Jan E, Kuehne, Ana I, Ruthel, Gordon, Pfeffer, Suzanne R, Dye, John M, Whelan, Sean P, Brummelkamp, Thijn R, Chandran, Kartik
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Chichester, UK John Wiley & Sons, Ltd 18.04.2012 Nature Publishing Group UK Springer Nature B.V Nature Publishing Group
Témata:	Animals Binding sites Carrier Proteins - metabolism Cell Line Cholesterol Ebola virus Ebolavirus - physiology EMBO20 EMBO23 Filovirus Glycoproteins Humans Marburg virus Membrane Glycoproteins - metabolism Membranes Microbiology Models, Biological Models, Molecular Molecular biology Niemann-Pick C1 Outbreaks Protein Binding Receptors, Virus - metabolism Viperidae viral entry Viral Envelope Proteins - chemistry Viral Envelope Proteins - metabolism viral receptor Virus Internalization Ebola virus viral entry Marburg virus Niemann‐Pick C1 viral receptor
ISSN:	0261-4189, 1460-2075, 1460-2075
On-line přístup:	Získat plný text
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