Standardization of measurements of 25-Hydroxyvitamin D3 and D2

Abstract The vitamin D status is increasingly assessed/monitored in different populations, research cohorts and individual patients. This is done by measuring the liver metabolites 25-hydroxyvitamin D3 and D2 as biomarkers. Recommendations for using specific serum concentrations of these biomarkers...

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Vydáno v:Scandinavian journal of clinical & laboratory investigation. Supplement Ročník 72; číslo S243; s. 41 - 49
Hlavní autoři: Thienpont, Linda M., Stepman, Hedwig C. M., Vesper, Hubert W.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Colchester Informa Healthcare 01.04.2012
Taylor & Francis
Informa
Témata:
25-Hydroxyvitamin D 2 - blood
3-epi-25-hydroxyvitamin D
Analytical performance goals
Biological and medical sciences
Calcifediol - blood
Calibration
DEQAS
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Reference Standards
total 25-hydroxyvitamin D
traceability
VDSP
Vitamin D Standardization Program
Performance evaluation
Program
VDSP
Steroid hormone
Calcitriol
Standardization
Analytical performance goals
Traceability
total 25-hydroxyvitamin D
Vitamin D
3-epi-25-hydroxyvitamin D
Clinical biology
Cholecalciferol(25-hydroxy)
Standardization Program
Performance
DEQAS
Quantitative analysis
ISSN:0036-5513, 2166-1030, 0085-591X, 1502-7686, 2166-1030
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Shrnutí:Abstract The vitamin D status is increasingly assessed/monitored in different populations, research cohorts and individual patients. This is done by measuring the liver metabolites 25-hydroxyvitamin D3 and D2 as biomarkers. Recommendations for using specific serum concentrations of these biomarkers to assess a person's vitamin D status were done. This requires current vitamin D assays to be sufficiently accurate over time, location and laboratory procedures. In view of the fact that several studies demonstrated that current 25(OH)D measurement methods do not meet this prerequisite, standardization is needed. This paper rehearses the basic concept of standardization, in particular applied to measurements of 25-hydroxyvitamin D. Progress has been made by establishing a reference measurement system consisting of reference methods and reference materials. Coordinated efforts to improve the accuracy and standardize measurements are being performed by organizations such as the U.S. NIH, the CDC and Prevention, the NIST together with their national and international partners. Beyond describing the available reference measurement system and its use as calibration hierarchy to establish traceability of measurements with routine laboratory methods to the SI-unit, this report will also focus on other aspects considered essential for a successful and sustainable standardization, such as analytical issues related to the definition of the measurand and analytical performance goals.
Bibliografie:ObjectType-Article-1
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content type line 23
ISSN:0036-5513
2166-1030
0085-591X
1502-7686
2166-1030
DOI:10.3109/00365513.2012.681950