Standardization of measurements of 25-Hydroxyvitamin D3 and D2

Abstract The vitamin D status is increasingly assessed/monitored in different populations, research cohorts and individual patients. This is done by measuring the liver metabolites 25-hydroxyvitamin D3 and D2 as biomarkers. Recommendations for using specific serum concentrations of these biomarkers...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Scandinavian journal of clinical & laboratory investigation. Supplement Jg. 72; H. S243; S. 41 - 49
Hauptverfasser: Thienpont, Linda M., Stepman, Hedwig C. M., Vesper, Hubert W.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Colchester Informa Healthcare 01.04.2012
Taylor & Francis
Informa
Schlagworte:
25-Hydroxyvitamin D 2 - blood
3-epi-25-hydroxyvitamin D
Analytical performance goals
Biological and medical sciences
Calcifediol - blood
Calibration
DEQAS
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Reference Standards
total 25-hydroxyvitamin D
traceability
VDSP
Vitamin D Standardization Program
Performance evaluation
Program
VDSP
Steroid hormone
Calcitriol
Standardization
Analytical performance goals
Traceability
total 25-hydroxyvitamin D
Vitamin D
3-epi-25-hydroxyvitamin D
Clinical biology
Cholecalciferol(25-hydroxy)
Standardization Program
Performance
DEQAS
Quantitative analysis
ISSN:0036-5513, 2166-1030, 0085-591X, 1502-7686, 2166-1030
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Abstract Abstract The vitamin D status is increasingly assessed/monitored in different populations, research cohorts and individual patients. This is done by measuring the liver metabolites 25-hydroxyvitamin D3 and D2 as biomarkers. Recommendations for using specific serum concentrations of these biomarkers to assess a person's vitamin D status were done. This requires current vitamin D assays to be sufficiently accurate over time, location and laboratory procedures. In view of the fact that several studies demonstrated that current 25(OH)D measurement methods do not meet this prerequisite, standardization is needed. This paper rehearses the basic concept of standardization, in particular applied to measurements of 25-hydroxyvitamin D. Progress has been made by establishing a reference measurement system consisting of reference methods and reference materials. Coordinated efforts to improve the accuracy and standardize measurements are being performed by organizations such as the U.S. NIH, the CDC and Prevention, the NIST together with their national and international partners. Beyond describing the available reference measurement system and its use as calibration hierarchy to establish traceability of measurements with routine laboratory methods to the SI-unit, this report will also focus on other aspects considered essential for a successful and sustainable standardization, such as analytical issues related to the definition of the measurand and analytical performance goals.
AbstractList Abstract The vitamin D status is increasingly assessed/monitored in different populations, research cohorts and individual patients. This is done by measuring the liver metabolites 25-hydroxyvitamin D3 and D2 as biomarkers. Recommendations for using specific serum concentrations of these biomarkers to assess a person's vitamin D status were done. This requires current vitamin D assays to be sufficiently accurate over time, location and laboratory procedures. In view of the fact that several studies demonstrated that current 25(OH)D measurement methods do not meet this prerequisite, standardization is needed. This paper rehearses the basic concept of standardization, in particular applied to measurements of 25-hydroxyvitamin D. Progress has been made by establishing a reference measurement system consisting of reference methods and reference materials. Coordinated efforts to improve the accuracy and standardize measurements are being performed by organizations such as the U.S. NIH, the CDC and Prevention, the NIST together with their national and international partners. Beyond describing the available reference measurement system and its use as calibration hierarchy to establish traceability of measurements with routine laboratory methods to the SI-unit, this report will also focus on other aspects considered essential for a successful and sustainable standardization, such as analytical issues related to the definition of the measurand and analytical performance goals.
The vitamin D status is increasingly assessed/monitored in different populations, research cohorts and individual patients. This is done by measuring the liver metabolites 25-hydroxyvitamin D3 and D2 as biomarkers. Recommendations for using specific serum concentrations of these biomarkers to assess a person’s vitamin D status were done. This requires current vitamin D assays to be sufficiently accurate over time, location and laboratory procedures. In view of the fact that several studies demonstrated that current 25(OH)D measurement methods do not meet this prerequisite, standardization is needed. This paper rehearses the basic concept of standardization, in particular applied to measurements of 25-hydroxyvitamin D. Progress has been made by establishing a reference measurement system consisting of reference methods and reference materials. Coordinated efforts to improve the accuracy and standardize measurements are being performed by organizations such as the U.S. NIH, the CDC and Prevention, the NIST together with their national and international partners. Beyond describing the available reference measurement system and its use as calibration hierarchy to establish traceability of measurements with routine laboratory methods to the SI-unit, this report will also focus on other aspects considered essential for a successful and sustainable standardization, such as analytical issues related to the definition of the measurand and analytical performance goals.
The vitamin D status is increasingly assessed/monitored in different populations, research cohorts and individual patients. This is done by measuring the liver metabolites 25-hydroxyvitamin D3 and D2 as biomarkers. Recommendations for using specific serum concentrations of these biomarkers to assess a person's vitamin D status were done. This requires current vitamin D assays to be sufficiently accurate over time, location and laboratory procedures. In view of the fact that several studies demonstrated that current 25(OH)D measurement methods do not meet this prerequisite, standardization is needed. This paper rehearses the basic concept of standardization, in particular applied to measurements of 25-hydroxyvitamin D. Progress has been made by establishing a reference measurement system consisting of reference methods and reference materials. Coordinated efforts to improve the accuracy and standardize measurements are being performed by organizations such as the U.S. NIH, the CDC and Prevention, the NIST together with their national and international partners. Beyond describing the available reference measurement system and its use as calibration hierarchy to establish traceability of measurements with routine laboratory methods to the SI-unit, this report will also focus on other aspects considered essential for a successful and sustainable standardization, such as analytical issues related to the definition of the measurand and analytical performance goals.The vitamin D status is increasingly assessed/monitored in different populations, research cohorts and individual patients. This is done by measuring the liver metabolites 25-hydroxyvitamin D3 and D2 as biomarkers. Recommendations for using specific serum concentrations of these biomarkers to assess a person's vitamin D status were done. This requires current vitamin D assays to be sufficiently accurate over time, location and laboratory procedures. In view of the fact that several studies demonstrated that current 25(OH)D measurement methods do not meet this prerequisite, standardization is needed. This paper rehearses the basic concept of standardization, in particular applied to measurements of 25-hydroxyvitamin D. Progress has been made by establishing a reference measurement system consisting of reference methods and reference materials. Coordinated efforts to improve the accuracy and standardize measurements are being performed by organizations such as the U.S. NIH, the CDC and Prevention, the NIST together with their national and international partners. Beyond describing the available reference measurement system and its use as calibration hierarchy to establish traceability of measurements with routine laboratory methods to the SI-unit, this report will also focus on other aspects considered essential for a successful and sustainable standardization, such as analytical issues related to the definition of the measurand and analytical performance goals.
Author Stepman, Hedwig C. M.
Thienpont, Linda M.
Vesper, Hubert W.
AuthorAffiliation 1 Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium
2 Centers for Disease Control and Prevention (CDC), Division of Laboratory Sciences, 4770 Buford Highway, MS F25, Atlanta, GA 30341, United States
AuthorAffiliation_xml – name: 1 Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium
– name: 2 Centers for Disease Control and Prevention (CDC), Division of Laboratory Sciences, 4770 Buford Highway, MS F25, Atlanta, GA 30341, United States
Author_xml – sequence: 1
  givenname: Linda M.
  surname: Thienpont
  fullname: Thienpont, Linda M.
  email: linda.thienpont@ugent.be, linda.thienpont@ugent.be
  organization: Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University
– sequence: 2
  givenname: Hedwig C. M.
  surname: Stepman
  fullname: Stepman, Hedwig C. M.
  email: linda.thienpont@ugent.be, linda.thienpont@ugent.be
  organization: Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University
– sequence: 3
  givenname: Hubert W.
  surname: Vesper
  fullname: Vesper, Hubert W.
  email: linda.thienpont@ugent.be, linda.thienpont@ugent.be
  organization: Centers for Disease Control and Prevention (CDC), Division of Laboratory Sciences
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26141567$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/22536761$$D View this record in MEDLINE/PubMed
BookMark eNp9kU1v1DAQhi1URLdb_gFCuVTiksUfsZ1cWlUtUKRKHNq7NbEd1lViFzvZsv31dbS7FC4cRtZonnlnPO8JOvLBW4Q-ELxiBDefMWaCc8JWFBO6EjVpOH6DFoRjWkpRiyO0mJFyZo7RSUoPOOesrt6hY0o5E1KQBTq_G8EbiMY9w-iCL0JXDBbSFO1g_ZjmnPLyZmti-L3duBEG54trVuSu4pqeorcd9Mm-379LdP_1y_3VTXn749v3q8vb0lVYjqXGpAJipWxajo2oq9bU2miNW1JVUuflGbStpAZDbWjXaiOANi3TBComMVui853s49QO1ui8WYRePUY3QNyqAE79W_FurX6GjeJZmeZYok97gRh-TTaNanBJ274Hb8OUFMEEC1bTfKAl-vj3rD9DDjfLwNkegKSh7yJ47dIrJ0hFuJCZu9hxznchDvAUYm_UCNs-xENTdnKORh3cVLObaufm67f3CmsL_bjWEK16CFP0-eLqvwIv6pKk_w
CODEN SJCLAY
ContentType Journal Article
Copyright 2012 Informa Healthcare 2012
2015 INIST-CNRS
Copyright_xml – notice: 2012 Informa Healthcare 2012
– notice: 2015 INIST-CNRS
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOI 10.3109/00365513.2012.681950
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList

MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Anatomy & Physiology
EISSN 1502-7686
2166-1030
EndPage 49
ExternalDocumentID PMC5813281
22536761
26141567
681950
10_3109_00365513_2012_681950
Genre Research Article
Journal Article
GrantInformation_xml – fundername: Intramural CDC HHS
  grantid: CC999999
GroupedDBID ---
-~X
.55
.GJ
00X
03L
08R
0BK
0R~
123
34G
36B
39C
3O-
4.4
53G
5RE
5VS
AAJNR
AALIY
AALUX
AAMIU
AAPUL
AAPXX
AAQQT
AAQRR
AAUGY
AAWTL
ABBKH
ABDBF
ABEIZ
ABLJU
ABLKL
ABOCM
ABPTK
ABUPF
ABWCV
ABZEW
ACENM
ACFUF
ACGEJ
ACGFS
ACKZS
ACLSK
ADCVX
ADFCX
ADFOM
ADFZZ
ADRBQ
ADXPE
AECIN
AEIIZ
AENEX
AEOZL
AEYQI
AFFNX
AFKVX
AFLEI
AFWLO
AGDLA
AGFJD
AGRBW
AGYJP
AIJEM
AIRBT
AJVHN
AJWEG
AKBVH
ALIIL
ALMA_UNASSIGNED_HOLDINGS
ALQZU
AMDAE
AWYRJ
BABNJ
BLEHA
BOHLJ
BRMBE
CAG
CCCUG
COF
CS3
CYYVM
CZDIS
DKSSO
DRXRE
DU5
DWTOO
EAP
EAS
EBB
EBC
EBD
EBS
EBX
EHN
EJD
EMB
EMK
EMOBN
EPL
EPT
ESX
F5P
H13
HZ~
J.N
JENTW
KRBQP
KSSTO
KWAYT
KYCEM
L7B
LJTGL
M44
M4Z
O9-
OVD
P2P
QQXMO
Q~Q
RNANH
RVRKI
SV3
TEORI
TFDNU
TFL
TFW
TUS
UEQFS
UHWXJ
V1S
WH7
X7M
ZA5
ZGI
ZXP
~1N
AAGDL
ABJNI
ABLIJ
ABWVI
ABXYU
ACIEZ
ACUHS
AFRVT
ALYBC
AQTUD
TASJS
TBQAZ
TDBHL
TERGH
TUROJ
AAORF
ACOPL
ACYZI
ADYSH
IQODW
NUSFT
04C
ADBBV
BMSDO
CGR
CUY
CVF
ECM
EIF
EIHBH
MK0
NPM
7X8
5PM
ID FETCH-LOGICAL-i407t-c014a1e779b50d684bd8cdcc0b1447c6813abb72d0a8d2fbcd6a29b3c1a43703
IEDL.DBID TFW
ISICitedReferencesCount 73
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000303248300007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0036-5513
2166-1030
0085-591X
IngestDate Thu Aug 21 13:59:36 EDT 2025
Thu Jul 10 19:20:40 EDT 2025
Sat May 31 02:13:38 EDT 2025
Mon Jul 21 09:15:02 EDT 2025
Mon Oct 20 23:45:42 EDT 2025
Wed Jun 21 01:44:31 EDT 2023
IsPeerReviewed true
IsScholarly true
Issue S243
Keywords Performance evaluation
Program
VDSP
Steroid hormone
Calcitriol
Standardization
Analytical performance goals
Traceability
total 25-hydroxyvitamin D
Vitamin D
3-epi-25-hydroxyvitamin D
Clinical biology
Cholecalciferol(25-hydroxy)
Standardization Program
Performance
DEQAS
Quantitative analysis
Language English
License CC BY 4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-i407t-c014a1e779b50d684bd8cdcc0b1447c6813abb72d0a8d2fbcd6a29b3c1a43703
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 22536761
PQID 1010638203
PQPubID 23479
PageCount 9
ParticipantIDs informahealthcare_journals_10_3109_00365513_2012_681950
pascalfrancis_primary_26141567
pubmed_primary_22536761
informaworld_taylorfrancis_310_3109_00365513_2012_681950
proquest_miscellaneous_1010638203
pubmedcentral_primary_oai_pubmedcentral_nih_gov_5813281
PublicationCentury 2000
PublicationDate 2012-04-01
PublicationDateYYYYMMDD 2012-04-01
PublicationDate_xml – month: 04
  year: 2012
  text: 2012-04-01
  day: 01
PublicationDecade 2010
PublicationPlace Colchester
PublicationPlace_xml – name: Colchester
– name: Norway
PublicationTitle Scandinavian journal of clinical & laboratory investigation. Supplement
PublicationTitleAlternate Scand J Clin Lab Invest Suppl
PublicationYear 2012
Publisher Informa Healthcare
Taylor & Francis
Informa
Publisher_xml – name: Informa Healthcare
– name: Taylor & Francis
– name: Informa
SSID ssj0003384
ssj0026105
Score 2.2393408
Snippet Abstract The vitamin D status is increasingly assessed/monitored in different populations, research cohorts and individual patients. This is done by measuring...
The vitamin D status is increasingly assessed/monitored in different populations, research cohorts and individual patients. This is done by measuring the liver...
SourceID pubmedcentral
proquest
pubmed
pascalfrancis
informaworld
informahealthcare
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 41
SubjectTerms 25-Hydroxyvitamin D 2 - blood
3-epi-25-hydroxyvitamin D
Analytical performance goals
Biological and medical sciences
Calcifediol - blood
Calibration
DEQAS
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Reference Standards
total 25-hydroxyvitamin D
traceability
VDSP
Vitamin D Standardization Program
Title Standardization of measurements of 25-Hydroxyvitamin D3 and D2
URI https://www.tandfonline.com/doi/abs/10.3109/00365513.2012.681950
https://www.ncbi.nlm.nih.gov/pubmed/22536761
https://www.proquest.com/docview/1010638203
https://pubmed.ncbi.nlm.nih.gov/PMC5813281
Volume 72
WOSCitedRecordID wos000303248300007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAWR
  databaseName: Taylor & Francis Journals
  customDbUrl:
  eissn: 1502-7686
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0026105
  issn: 0036-5513
  databaseCode: TFW
  dateStart: 19510101
  isFulltext: true
  titleUrlDefault: https://www.tandfonline.com
  providerName: Taylor & Francis
– providerCode: PRVAWR
  databaseName: Taylor & Francis Journals
  customDbUrl:
  eissn: 1502-7686
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0003384
  issn: 0036-5513
  databaseCode: TFW
  dateStart: 19490101
  isFulltext: true
  titleUrlDefault: https://www.tandfonline.com
  providerName: Taylor & Francis
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEB50EdGD78f6WCp4rbRJ27QXQdTFiyK44N5CkjbYg13ZrYL_3pm2-_J10GNoJyQzecyXTL4BOLWBZiJNuGu5QIDC0RbaGuGGuBczEycqikyVbELc3cX9fnI_84qfwioJQ9uaKKJaq2lyK11lICEeS8o_FlFeEgrMYmcR3QQRaEfHnoZ4r_s4WYoRfwVj1l2SqN_O_VjJKmw0dKVPk-CrTxSmFDupRqg-W-e9-M4x_RxfObNhddf_39UNWGucVeeiHl2bsJAVW7B821zHb8P5Q3MQ0TzmdAbWeZ4eOo6ozEL35j2lYJm3vFTPeeFccQelnCu2A73ude_yxm0SMrg54r7SNYinlJ8JkejQS6M40JT7yBhPIywTBpvHldaCpZ6KU2a1SSPFEs2NrwKOS8sutIpBke2Do6gOlfnaM35ggzRJQvQ0bCJ0lqHPGrZBfLGEbGbXSCJwIe3IsXYkaUfW2mlDPGsvWVYHH421SOw30c6cbeVLTfghEWUSzhVtOBkbW-IspKsVVWSDV2qRT74f83gb9mrjT6VZSLR4PvZpblhMfiCG7_kvRf5UMX2jUjiL_YO_9-kQVqhUxxodQascvmbHsGTeynw07MCi6Medas58ABp0EzA
linkProvider Taylor & Francis
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LT9wwEB5VtCrtoVCe2wJNJa6BxE7i-FKpKl1tVVhV6kpws2wnFjmQrUhA4t8zk3gXlrYcEMfIGcue8WM--_MMwL5LDBOF5KHjAgEKR1sYZ0WY4l7MbC51ltku2YQYj_OzM_nLswkbT6skDO36QBHdWk2Tmw6jDzuIGUlKQJZRYhJiZrGDjK6CELW_THGrJVbfZHg6X4wRgSWzuLsk0r-e-28tb2HVByw9n9OvHgQxJfakblCBrs988S_X9CHD8t6WNVx5hs6uwjvvrwZf-wH2Hl6U9Rq8PvE38uvw5bc_i_DvOYOpCy7uzh0b-mZpOLopiC9zXbX6oqqDIx6gVHDENmAy_D75Ngp9ToawQujXhhYhlY5LIaRJoyLLE0Ppj6yNDCIzYbF5XBsjWBHpvGDO2CLTTBpuY51wXF02Yame1uU2BJrq0GVsIhsnLimkTNHZcFKYskS3NR2A-MsUyk-wRiF2Ie2omXYUaUf12hlAft9gqu3OPry5SOwx0b0F46o_fcwPhUCToK4YwOeZtRVORLpd0XU5vaIWxeT-sYgPYKu3_p00SykyXox9WhgX8x8oyPdiSV2dd8G-USmc5fGHp_fpEyyPJifH6vjH-OdHeEMlPfVoB5bay6tyF17Z67ZqLve6qXML1rcWaQ
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3dT9swED9NgNB44GsDCgOCxGu2xE7i-AUJrauYNiokKsGbZTuxyAMpomkl_nvukrS0MPawPUbOWfadP-5nn38HcOoiw0Qmue-4QIDC0RbGWeHHuBczm0qdJLZONiH6_fT2Vl7NveKnsErC0K4hiqjXaprcD5n7ViPMQFL-sYTyklBgFvua0E0QgvblmhsLR_SgdzNbixGARVPaXRJpHs-9W8sabLZ8pXez6KtXHKYUPKlHqD_XJL74k2f6OsBybsfqbfx_XzdhvfVWvfNmeG3Bh7zchtXL9j7-E5xdtycR7WtOb-i8-5dTxxF9s9i_eMooWmZSVPq-KL0u91DK67LPMOj9GHy_8NuMDH6BwK_yLQIqHeZCSBMHWZJGhpIfWRsYxGXCYvO4NkawLNBpxpyxWaKZNNyGOuK4tuzAUjks8z3wNNWh89AENoxclEkZo6vhpDB5jk5r3AHxxhKqnV4jhciFtKOm2lGkHdVopwPpvL1UVZ98tNYisb-JHi3YVj00jB8KYSYBXdGBk6mxFU5DulvRZT4cU4tCcv5YwDuw2xj_RZrFxIsXYp8WhsXsB6L4Xiwpi7ua6huVwlka7v97n45h9arbU79_9n8dwEcqaOKOvsBS9TjOD2HFTqpi9HhUT5xnViwVDQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Standardization+of+measurements+of+25-Hydroxyvitamin+D3+and+D2&rft.jtitle=Scandinavian+journal+of+clinical+%26+laboratory+investigation.+Supplement&rft.au=Thienpont%2C+Linda+M.&rft.au=Stepman%2C+Hedwig+C.+M.&rft.au=Vesper%2C+Hubert+W.&rft.date=2012-04-01&rft.issn=0085-591X&rft.eissn=2166-1030&rft.volume=243&rft.spage=41&rft.epage=49&rft_id=info:doi/10.3109%2F00365513.2012.681950&rft_id=info%3Apmid%2F22536761&rft.externalDocID=PMC5813281
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0036-5513&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0036-5513&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0036-5513&client=summon