CCR3 induced-p42/44 MAPK activation protects against staurosporine induced-DNA fragmentation but not apoptosis in airway smooth muscle cells

Summary Background Chemokine receptors (CCRs) are expressed on airway smooth muscle (ASM) cells. As their ligands are present in the airways in asthma, we hypothesized that ASM CCR activation could promote the increase in ASM mass seen in patients with chronic asthma. Objective To determine which CC...

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Bibliographic Details
Published in:	Clinical and experimental allergy Vol. 42; no. 7; pp. 1040 - 1050
Main Authors:	Markwick, L. J., Clements, D., Roberts, M. E., Ceresa, C. C., Knox, A. J., Johnson, S. R.
Format:	Journal Article
Language:	English
Published:	Oxford Blackwell Publishing Ltd 01.07.2012 Blackwell Wiley Subscription Services, Inc
Subjects:	airway remodelling AKT protein Apoptosis Apoptosis - drug effects Asthma Asthma - metabolism Asthma - pathology Biological and medical sciences Biopsy Bronchi - metabolism Bronchi - pathology Caspase 3 - metabolism Caspase-3 CD95 antigen Cell culture Cells, Cultured chemokine Chemokine receptors Chronic obstructive pulmonary disease, asthma CX3CR1 protein DNA fragmentation DNA Fragmentation - drug effects Enzyme Activation - drug effects Enzyme Inhibitors - adverse effects Enzyme Inhibitors - pharmacology Epithelium Fas antigen Female Flow cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunohistochemistry Male MAP kinase Medical sciences Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Myocytes, Smooth Muscle - metabolism Myocytes, Smooth Muscle - pathology Pneumology Polymerase chain reaction Receptors, CCR3 - biosynthesis Respiratory tract Smooth muscle Staurosporine Staurosporine - adverse effects Staurosporine - pharmacology Thymidine Vascular endothelial growth factor Western blotting Lung disease Enzyme Respiratory disease Transferases airway remodelling Mitogen-activated protein kinase Smooth muscle Activation Chemokine receptor CCR3 chemokine receptor Remodeling Respiratory system Asthma Fragmentation Myocyte Chemokine Respiratory tract Immunology Cell death DNA Bronchus disease Obstructive pulmonary disease Protection Apoptosis
ISSN:	0954-7894, 1365-2222, 1365-2222
Online Access:	Get full text
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